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Predicting tumor cell line response to drug pairs with deep learning.

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第一作者： Fangfang,Xia

第一单位： Computing, Environment and Life Sciences, Argonne National Laboratory, Lemont, IL, USA. fangfang@anl.gov.;Computation Institute, The University of Chicago, Chicago, IL, USA. fangfang@anl.gov.

作者： Fangfang,Xia ^[1] ; Maulik,Shukla ^[2] ; Thomas,Brettin ^[2] ; Cristina,Garcia-Cardona ^[3] ; Judith,Cohn ^[4] ; Jonathan E,Allen ^[5] ; Sergei,Maslov ^[6] ; Susan L,Holbeck ^[7] ; James H,Doroshow ^[7] ; Yvonne A,Evrard ^[7] ; Eric A,Stahlberg ^[8] ; Rick L,Stevens ^[9]

作者单位： Computing, Environment and Life Sciences, Argonne National Laboratory, Lemont, IL, USA. fangfang@anl.gov.;Computation Institute, The University of Chicago, Chicago, IL, USA. fangfang@anl.gov. ^[1] Computing, Environment and Life Sciences, Argonne National Laboratory, Lemont, IL, USA. ^[2] Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM, USA. ^[3] Computer Science, Los Alamos National Laboratory, Los Alamos, NM, USA. ^[4] Computation Directorate, Lawrence Livermore National Laboratory, Livermore, CA, USA. ^[5] Department of Bioengineering and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA. ^[6] Developmental Therapeutics Branch, National Cancer Institute, Frederick, MD, USA. ^[7] Data Science and Information Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA. ^[8] Computing, Environment and Life Sciences, Argonne National Laboratory, Lemont, IL, USA.;Computation Institute, The University of Chicago, Chicago, IL, USA. ^[9]

关键词 Combination therapy Deep learning Machine learning in silico drug screening

医学主题词细胞系, 肿瘤(Cell Line, Tumor);药物评价, 临床前(Drug Evaluation, Preclinical);人类(Humans);国立癌症研究所(美国)(National Cancer Institute (U.S.));美国(United States)

DOI 10.1186/s12859-018-2509-3

PMID 30577754

发布时间 2025-05-30

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