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The depolymerase activity of MCAK shows a graded response to Aurora B kinase phosphorylation through allosteric regulation.

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第一作者： Toni,McHugh

第一单位： Wellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, UK.

作者： Toni,McHugh ^[1] ; Juan,Zou ^[1] ; Vladimir A,Volkov ^[2] ; Aurélie,Bertin ^[3] ; Sandeep K,Talapatra ^[1] ; Juri,Rappsilber ^[4] ; Marileen,Dogterom ^[2] ; Julie P I,Welburn ^[5]

作者单位： Wellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, UK. ^[1] Department of Bionanoscience, Faculty of Applied Sciences, Delft University of Technology, Delft 2629, The Netherlands. ^[2] Laboratoire Physico Chimie Curie, Institut Curie, PSL Research University, CNRS UMR168, 75005 Paris, France.;Sorbonne Universités, UPMC University Paris 06, 75005 Paris, France. ^[3] Wellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, UK.;Chair of Bioanalytics, Institute of Biotechnology, Technische Universität Berlin, Berlin 10623, Germany. ^[4] Wellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, UK Julie.Welburn@ed.ac.uk. ^[5]

关键词 Aurora B MCAK Microtubules Phosphorylation