首页> European journal of medicinal chemistry> Unprecedented inhibition of P-gp activity by a novel ruthenium-cyclopentadienyl compound bearing a bipyridine-biotin ligand.

Unprecedented inhibition of P-gp activity by a novel ruthenium-cyclopentadienyl compound bearing a bipyridine-biotin ligand.

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第一作者： Leonor,Côrte-Real

第一单位： Centro de Química Estrutural, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016, Lisboa, Portugal.

作者： Leonor,Côrte-Real ^[1] ; Brittany,Karas ^[2] ; Patrícia,Gírio ^[3] ; Alexis,Moreno ^[4] ; Fernando,Avecilla ^[5] ; Fernanda,Marques ^[6] ; Brian T,Buckley ^[7] ; Keith R,Cooper ^[8] ; Cathleen,Doherty ^[7] ; Pierre,Falson ^[4] ; M Helena,Garcia ^[1] ; Andreia,Valente ^[9]

作者单位： Centro de Química Estrutural, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016, Lisboa, Portugal. ^[1] Environmental and Occupational Health Sciences Institute, Rutgers University, 170 Frelinghuysen Road, Piscataway, NJ, 08854, USA; Department of Biochemistry and Microbiology, Rutgers University, 76 Lipman Drive, New Brunswick, NJ, 08854, USA. ^[2] Centro de Química Estrutural, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016, Lisboa, Portugal; Drug Resistance and Membrane Proteins Team, Molecular Biology and Structural Biochemistry Laboratory, UMR 5086 CNRS-UCBL1, IBCP 7 Passage du Vercors, 69 367, Lyon Cedex 07, France. ^[3] Drug Resistance and Membrane Proteins Team, Molecular Biology and Structural Biochemistry Laboratory, UMR 5086 CNRS-UCBL1, IBCP 7 Passage du Vercors, 69 367, Lyon Cedex 07, France. ^[4] Grupo Xenomar, Centro de Investigacións Científicas Avanzadas (CICA), Departamento de Química, Facultade de Ciencias, Universidade da Coruña, Campus de A Coruña, 15071 A, Coruña, Spain. ^[5] Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10, Km 139.7, 2695-066, Bobadela LRS, Portugal. ^[6] Environmental and Occupational Health Sciences Institute, Rutgers University, 170 Frelinghuysen Road, Piscataway, NJ, 08854, USA. ^[7] Department of Biochemistry and Microbiology, Rutgers University, 76 Lipman Drive, New Brunswick, NJ, 08854, USA. ^[8] Centro de Química Estrutural, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016, Lisboa, Portugal. Electronic address: amvalente@fc.ul.pt. ^[9]

关键词 Anticancer agents Multidrug resistance P-gp inhibitor Ruthenium organometallic compounds