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p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression.

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第一作者： Sung-Hwan,Moon

第一单位： Department of Biological Sciences, Columbia University, New York, NY 10027, USA.

作者： Sung-Hwan,Moon ^[1] ; Chun-Hao,Huang ^[2] ; Shauna L,Houlihan ^[3] ; Kausik,Regunath ^[1] ; William A,Freed-Pastor ^[1] ; John P,Morris ^[3] ; Darjus F,Tschaharganeh ^[3] ; Edward R,Kastenhuber ^[4] ; Anthony M,Barsotti ^[1] ; Rachel,Culp-Hill ^[5] ; Wen,Xue ^[6] ; Yu-Jui,Ho ^[3] ; Timour,Baslan ^[3] ; Xiang,Li ^[7] ; Allison,Mayle ^[3] ; Elisa,de Stanchina ^[3] ; Lars,Zender ^[6] ; David R,Tong ^[1] ; Angelo,D'Alessandro ^[5] ; Scott W,Lowe ^[8] ; Carol,Prives ^[9]

作者单位： Department of Biological Sciences, Columbia University, New York, NY 10027, USA. ^[1] Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Cell and Developmental Biology Program, Weill Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. ^[2] Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ^[3] Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ^[4] Department of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO 80045, USA. ^[5] Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. ^[6] Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Cell and Developmental Biology Program, Weill Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA. ^[7] Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: lowes@mskcc.org. ^[8] Department of Biological Sciences, Columbia University, New York, NY 10027, USA. Electronic address: clp3@columbia.edu. ^[9]

关键词 ABCA1 SREBP-2 cancer metabolism mevalonate pathway p53 tumor suppression