Recapitulation of methotrexate hepatotoxicity with induced pluripotent stem cell-derived hepatocytes from patients with rheumatoid arthritis.

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第一作者： Juryun,Kim

第一单位： CiSTEM laboratory, Convergent Research Consortium for Immunologic Disease, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, 137-701, Republic of Korea.

作者： Juryun,Kim ^[1] ; Yena,Kim ^[2] ; Jinhyeok,Choi ^[3] ; Hyerin,Jung ^[1] ; Kijun,Lee ^[2] ; Jaewoo,Kang ^[3] ; Narae,Park ^[1] ; Yeri Alice,Rim ^[2] ; Yoojun,Nam ^[3] ; Ji Hyeon,Ju ^[1]

作者单位： CiSTEM laboratory, Convergent Research Consortium for Immunologic Disease, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, 137-701, Republic of Korea. ^[1] Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, Institute of Medical Science, College of Medicine, The Catholic University of Korea, #505, Banpo-Dong, Seocho-Gu, Seoul, 137-701, Republic of Korea. ^[2] Department of Biomedicine & Health Sciences, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, 137-701, Republic of Korea. ^[3] CiSTEM laboratory, Convergent Research Consortium for Immunologic Disease, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, 137-701, Republic of Korea. juji@catholic.ac.kr. ^[4] Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, Institute of Medical Science, College of Medicine, The Catholic University of Korea, #505, Banpo-Dong, Seocho-Gu, Seoul, 137-701, Republic of Korea. juji@catholic.ac.kr. ^[5]

关键词 Drug-induced hepatotoxicity Hepatocyte Hepatocyte spheroid Induced pluripotent stem cells Methotrexate Rheumatoid arthritis

主题词抗代谢药, 抗肿瘤(Antimetabolites, Antineoplastic);关节炎, 类风湿(Arthritis, Rheumatoid);细胞分化(Cell Differentiation);肝细胞(Hepatocytes);人类(Humans);诱导多能干细胞(Induced Pluripotent Stem Cells);甲氨蝶呤(Methotrexate)

DOI 10.1186/s13287-018-1100-1

PMID 30594247

发布时间 2020-03-09

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