The Translation Inhibitor Rocaglamide Targets a Bimolecular Cavity between eIF4A and Polypurine RNA.-论文-万方医学网

第一作者： Shintaro,Iwasaki

第一单位： Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; RNA Systems Biochemistry Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama 351-0198, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo 277-8561, Japan. Electronic address: shintaro.iwasaki@riken.jp.

作者： Shintaro,Iwasaki ^[1] ; Wakana,Iwasaki ^[2] ; Mari,Takahashi ^[2] ; Ayako,Sakamoto ^[2] ; Chiduru,Watanabe ^[3] ; Yuichi,Shichino ^[4] ; Stephen N,Floor ^[5] ; Koichi,Fujiwara ^[6] ; Mari,Mito ^[4] ; Kosuke,Dodo ^[7] ; Mikiko,Sodeoka ^[7] ; Hiroaki,Imataka ^[8] ; Teruki,Honma ^[3] ; Kaori,Fukuzawa ^[9] ; Takuhiro,Ito ^[10] ; Nicholas T,Ingolia ^[11]

作者单位： Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; RNA Systems Biochemistry Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama 351-0198, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo 277-8561, Japan. Electronic address: shintaro.iwasaki@riken.jp. ^[1] Laboratory for Translation Structural Biology, RIKEN Center for Biosystems Dynamics Research, Tsurumi-ku, Yokohama 230-0045, Japan; Division of Structural and Synthetic Biology, RIKEN Center for Life Science Technologies, Tsurumi-ku, Yokohama 230-0045, Japan. ^[2] Division of Structural and Synthetic Biology, RIKEN Center for Life Science Technologies, Tsurumi-ku, Yokohama 230-0045, Japan; Laboratory for Structure-Based Molecular Design, RIKEN Center for Biosystems Dynamics Research, Tsurumi-ku, Yokohama 230-0045, Japan. ^[3] RNA Systems Biochemistry Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama 351-0198, Japan. ^[4] Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA. ^[5] Synthetic Organic Chemistry Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama 351-0198, Japan. ^[6] Synthetic Organic Chemistry Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama 351-0198, Japan; AMED-CREST, Japan Agency for Medical Research and Development, Wako, Saitama 351-0198, Japan; RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan. ^[7] Graduate School of Engineering, University of Hyogo, Himeji, Hyogo 671-2201, Japan. ^[8] School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo 142-8501, Japan. ^[9] Laboratory for Translation Structural Biology, RIKEN Center for Biosystems Dynamics Research, Tsurumi-ku, Yokohama 230-0045, Japan; Division of Structural and Synthetic Biology, RIKEN Center for Life Science Technologies, Tsurumi-ku, Yokohama 230-0045, Japan. Electronic address: takuhiro.ito@riken.jp. ^[10] Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: ingolia@berkeley.edu. ^[11]

主题词腺苷酰亚氨二磷酸(Adenylyl Imidodiphosphate);米仔兰属(Aglaia);氨基酸取代(Amino Acid Substitution);苯呋喃类(Benzofurans);结合部位(Binding Sites);抗药性(Drug Resistance);真核细胞起始因子4A(Eukaryotic Initiation Factor-4A);HEK293细胞(HEK293 Cells);人类(Humans);模型, 分子(Models, Molecular);分子结构(Molecular Structure);突变(Mutation);植物蛋白质类(Plant Proteins);蛋白质结合(Protein Binding);蛋白质生物合成(Protein Biosynthesis);蛋白质相互作用域和基序(Protein Interaction Domains and Motifs);蛋白质合成抑制药(Protein Synthesis Inhibitors);RNA(RNA);核糖体(Ribosomes);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.molcel.2018.11.026

PMID 30595437

发布时间 2024-07-14

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The Translation Inhibitor Rocaglamide Targets a Bimolecular Cavity between eIF4A and Polypurine RNA.

Molecular cell

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Molecular cell

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The Translation Inhibitor Rocaglamide Targets a Bimolecular Cavity between eIF4A and Polypurine RNA.

Molecular cell

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Molecular cell

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