Different Effects of α-Synuclein Mutants on Lipid Binding and Aggregation Detected by Single Molecule Fluorescence Spectroscopy and ThT Fluorescence-Based Measurements.

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作者： Viktoria C,Ruf ^[1] ; Georg S,Nübling ^[1] ; Sophia,Willikens ^[2] ; Song,Shi ^[1] ; Felix,Schmidt ^[1] ; Johannes,Levin ^[1] ; Kai,Bötzel ^[2] ; Frits,Kamp ^[3] ; Armin,Giese ^[2]

作者单位： Center for Neuropathology and Prion Research , Ludwig-Maximilians-University , Munich 81377 , Germany. ^[1] Department of Neurology , University Hospital Munich, Ludwig-Maximilians-University , Munich 81377 , Germany. ^[2] German Center for Neurodegenerative Diseases , Munich 81377 , Germany. ^[3] Biomedical Center, Metabolic Biochemistry , Ludwig-Maximilians-University , Munich 81377 , Germany. ^[4]

关键词 Parkinson’s disease mutant protein aggregation protein?lipid interaction synucleinopathy α-Synuclein

主题词人类(Humans);脂类(Lipids);突变(Mutation);帕金森病(Parkinson Disease);点突变(Point Mutation);光谱法, 荧光(Spectrometry, Fluorescence);α突触核蛋白(alpha-Synuclein)

DOI 10.1021/acschemneuro.8b00579

PMID 30605594

发布时间 2020-03-31

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