Cryo-EM Structures of the Hsp104 Protein Disaggregase Captured in the ATP Conformation.

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第一作者： Sukyeong,Lee

第一单位： Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: slee@bcm.edu.

作者： Sukyeong,Lee ^[1] ; Soung Hun,Roh ^[2] ; Jungsoon,Lee ^[2] ; Nuri,Sung ^[2] ; Jun,Liu ^[3] ; Francis T F,Tsai ^[4]

作者单位： Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: slee@bcm.edu. ^[1] Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA. ^[2] Department of Pathology and Laboratory Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA. ^[3] Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: ftsai@bcm.edu. ^[4]

关键词 AAA+ATPase ClpB Hsp104 cryo-EM molecular chaperone protein disaggregase

主题词腺苷三磷酸(Adenosine Triphosphate);冷冻电子显微镜检查(Cryoelectron Microscopy);人类(Humans);蛋白质构象(Protein Conformation)

DOI 10.1016/j.celrep.2018.12.037

PMID 30605683

发布时间 2020-03-19

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