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WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop.

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第一作者： Megan J,Agajanian

第一单位： Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

作者： Megan J,Agajanian ^[1] ; Matthew P,Walker ^[2] ; Alison D,Axtman ^[3] ; Roberta R,Ruela-de-Sousa ^[4] ; D Stephen,Serafin ^[5] ; Alex D,Rabinowitz ^[2] ; David M,Graham ^[6] ; Meagan B,Ryan ^[1] ; Tigist,Tamir ^[1] ; Yuko,Nakamichi ^[7] ; Melissa V,Gammons ^[8] ; James M,Bennett ^[9] ; Rafael M,Couñago ^[4] ; David H,Drewry ^[3] ; Jonathan M,Elkins ^[10] ; Carina,Gileadi ^[9] ; Opher,Gileadi ^[10] ; Paulo H,Godoi ^[4] ; Nirav,Kapadia ^[3] ; Susanne,Müller ^[11] ; André S,Santiago ^[4] ; Fiona J,Sorrell ^[9] ; Carrow I,Wells ^[3] ; Oleg,Fedorov ^[9] ; Timothy M,Willson ^[3] ; William J,Zuercher ^[12] ; Michael B,Major ^[13]

作者单位： Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. ^[1] Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. ^[2] Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. ^[3] Structural Genomics Consortium, Universidade Estadual de Campinas - UNICAMP, Campinas, SP 13083-970, Brazil. ^[4] Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. ^[5] Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. ^[6] Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Institute for Oral Science, Matsumoto Dental University, Nagano 399-0704, Japan. ^[7] MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CB2 0SL, UK. ^[8] Structural Genomics Consortium and Target Discovery Institute, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK. ^[9] Structural Genomics Consortium, Universidade Estadual de Campinas - UNICAMP, Campinas, SP 13083-970, Brazil; Structural Genomics Consortium and Target Discovery Institute, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK. ^[10] Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt am Main 60438, Germany. ^[11] Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. ^[12] Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: benmajor@med.unc.edu. ^[13]

关键词 AAK1 AP2M1 LRP6 WNT signaling clathrin endocytosis feedback loop gain-of-function screen kinase