Tricarboxylic acid cycle activity suppresses acetylation of mitochondrial proteins during early embryonic development in <i>Caenorhabditis elegans</i>.

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作者： Kazumasa,Hada ^[1] ; Keiko,Hirota ^[2] ; Ai,Inanobe ^[3] ; Koichiro,Kako ^[4] ; Mai,Miyata ^[5] ; Sho,Araoi ^[6] ; Masaki,Matsumoto ^[3] ; Reiya,Ohta ^[4] ; Mitsuhiro,Arisawa ^[6] ; Hiroaki,Daitoku ^[6] ; Toshikatsu,Hanada ^[7] ; Akiyoshi,Fukamizu ^[8]

作者单位： From the Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8577, Japan. ^[1] Department of Cell Biology, Faculty of Medicine, Oita University, 1-1 Hasama-machi Idaigaoka, Yufu, Oita, 879-5593, Japan. ^[2] Ph.D. Program in Human Biology, School of Integrative and Global Majors, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8572, Japan. ^[3] Faculty of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8572, Japan the. ^[4] Department of Hygiene and Public Health, School of Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. ^[5] Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8572, Japan. ^[6] Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Fukuoka, Fukuoka 812-8582, Japan. ^[7] Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan, and. ^[8] From the Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8577, Japan, akif@tara.tsukuba.ac.jp. ^[9] International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, Japan. ^[10]

关键词 Caenorhabditis elegans (C. elegans)acetyl coenzyme A (acetyl-CoA)citrate synthase deacetylase early embryogenesis mitochondrial protein acetylation polyamine post-translational modification (PTM)sirtuin tricarboxylic acid cycle (TCA cycle) (Krebs cycle)