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A Genome-wide Framework for Mapping Gene Regulation via Cellular Genetic Screens.

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第一作者： Molly,Gasperini

第一单位： Department of Genome Sciences, University of Washington, Seattle, WA 98105, USA. Electronic address: gasperim@uw.edu.

作者： Molly,Gasperini ^[1] ; Andrew J,Hill ^[2] ; José L,McFaline-Figueroa ^[2] ; Beth,Martin ^[2] ; Seungsoo,Kim ^[2] ; Melissa D,Zhang ^[2] ; Dana,Jackson ^[2] ; Anh,Leith ^[2] ; Jacob,Schreiber ^[3] ; William S,Noble ^[4] ; Cole,Trapnell ^[5] ; Nadav,Ahituv ^[6] ; Jay,Shendure ^[7]

作者单位： Department of Genome Sciences, University of Washington, Seattle, WA 98105, USA. Electronic address: gasperim@uw.edu. ^[1] Department of Genome Sciences, University of Washington, Seattle, WA 98105, USA. ^[2] Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA 98105, USA. ^[3] Department of Genome Sciences, University of Washington, Seattle, WA 98105, USA; Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA 98105, USA. ^[4] Department of Genome Sciences, University of Washington, Seattle, WA 98105, USA; Brotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA 98105, USA. ^[5] Department of Bioengineering and Therapeutic Sciences, Institute for Human Genetics, University of California San Francisco, San Francisco, CA 94143, USA. ^[6] Department of Genome Sciences, University of Washington, Seattle, WA 98105, USA; Brotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA 98105, USA; Howard Hughes Medical Institute, Seattle, WA 98105, USA. Electronic address: shendure@uw.edu. ^[7]

关键词 CRISPR CRISPRi RNA-seq crisprQTL eQTL enhancer gene regulation genetic screen human genetics single cell