5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute Parkinson's disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells against oxidative stress.

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作者： Li-Li,Xu ^[1] ; Yu-Feng,Wu ^[2] ; Fang,Yan ^[2] ; Cui-Cui,Li ^[2] ; Zhen,Dai ^[2] ; Qi-Dong,You ^[3] ; Zheng-Yu,Jiang ^[4] ; Bin,Di ^[5]

作者单位： State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China; Key Laboratory on Protein Chemistry and Structural Biology, Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China. ^[1] Key Laboratory on Protein Chemistry and Structural Biology, Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China. ^[2] State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: youqd@cpu.edu.cn. ^[3] State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: jzy@cpu.edu.cn. ^[4] Key Laboratory on Protein Chemistry and Structural Biology, Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China. Electronic address: dibin@cpu.edu.cn. ^[5]

关键词 Brain targeting function NLRP3 inflammasome Nrf2-ARE activator Oxidative stress Parkinson's disease