GADD45A binds R-loops and recruits TET1 to CpG island promoters.-论文-万方医学网

作者： Khelifa,Arab ^[1] ; Emil,Karaulanov ^[2] ; Michael,Musheev ^[3] ; Philipp,Trnka ^[4] ; Andrea,Schäfer ^[4] ; Ingrid,Grummt ^[4] ; Christof,Niehrs ^[4]

作者单位： Institute of Molecular Biology (IMB), Mainz, Germany. k.arab@imb-mainz.de. ^[1] Division of Molecular Biology of the Cell II, German Cancer Research Center and DKFZ-ZMBH Alliance, Heidelberg, Germany. k.arab@imb-mainz.de. ^[2] Division of Molecular Embryology, German Cancer Research Center and DKFZ-ZMBH Alliance, Heidelberg, Germany. k.arab@imb-mainz.de. ^[3] Institute of Molecular Biology (IMB), Mainz, Germany. ^[4] Division of Molecular Biology of the Cell II, German Cancer Research Center and DKFZ-ZMBH Alliance, Heidelberg, Germany. i.grummt@dkfz.de. ^[5] Institute of Molecular Biology (IMB), Mainz, Germany. c.niehrs@imb-mainz.de. ^[6] Division of Molecular Embryology, German Cancer Research Center and DKFZ-ZMBH Alliance, Heidelberg, Germany. c.niehrs@imb-mainz.de. ^[7]

主题词动物(Animals);细胞周期(Cell Cycle);细胞周期蛋白质类(Cell Cycle Proteins);细胞系(Cell Line);染色质(Chromatin);CpG岛(CpG Islands);DNA甲基化(DNA Methylation);DNA结合蛋白质类(DNA-Binding Proteins);后成说, 遗传(Epigenesis, Genetic);表观基因组学(Epigenomics);HEK293细胞(HEK293 Cells);人类(Humans);小鼠(Mice);混合功能氧化酶类(Mixed Function Oxygenases);核蛋白质类(Nuclear Proteins);启动区, 遗传(Promoter Regions, Genetic);蛋白质结合(Protein Binding);原癌基因蛋白质类(Proto-Oncogene Proteins);核糖核酸酶H(Ribonuclease H);转录, 遗传(Transcription, Genetic)

DOI 10.1038/s41588-018-0306-6

PMID 30617255

发布时间 2020-03-09

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GADD45A binds R-loops and recruits TET1 to CpG island promoters.

Nature genetics

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GADD45A binds R-loops and recruits TET1 to CpG island promoters.

Nature genetics

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Nature genetics

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