Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension.

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作者： Haiyang,Tang ^[1] ; Kang,Wu ^[2] ; Jian,Wang ^[1] ; Sujana,Vinjamuri ^[2] ; Yali,Gu ^[1] ; Shanshan,Song ^[2] ; Ziyi,Wang ^[1] ; Qian,Zhang ^[1] ; Angela,Balistrieri ^[1] ; Ramon J,Ayon ^[1] ; Franz,Rischard ^[2] ; Rebecca,Vanderpool ^[1] ; Jiwang,Chen ^[2] ; Guofei,Zhou ^[3] ; Ankit A,Desai ^[1] ; Stephen M,Black ^[1] ; Joe G N,Garcia ^[1] ; Jason X-J,Yuan ^[4] ; Ayako,Makino ^[1]

作者单位： Division of Translational and Regenerative Medicine, The University of Arizona College of Medicine, Tucson, Arizona. ^[1] State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. ^[2] Department of Physiology, The University of Arizona College of Medicine, Tucson, Arizona. ^[3] Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, The University of Arizona College of Medicine, Tucson, Arizona. ^[4] Department of Pediatrics, University of Illinois College of Medicine, Chicago, Illinois. ^[5] Division of Cardiology, Department of Medicine, The University of Arizona College of Medicine, Tucson, Arizona. ^[6]

关键词 EC, endothelial cell FOXO3a, Forkhead box O3a GPCR, G protein-coupled receptor HPH, hypoxia-induced pulmonary hypertension PA, pulmonary artery PAEC, pulmonary arterial endothelial cell PAH, pulmonary arterial hypertension PASMC, pulmonary arterial smooth muscle cell PDGF, platelet-derived growth factor PDGFR, platelet-derived growth factor receptor PH, pulmonary hypertension PI3K, phosphoinositide 3-kinase PTEN, phosphatase and tensin homolog PVR, pulmonary vascular resistance RVH, right ventricular hypertrophy RVSP, right ventricular systolic pressure Raptor Raptor, regulatory associated protein of mammalian target of rapamycin Rictor Rictor, rapamycin insensitive companion of mammalian target of rapamycin SM, smooth muscle TKR, tyrosine kinase receptor WT, wild-type mTOR mTORC1, mammalian target of rapamycin complex 1 mTORC2, mammalian target of rapamycin complex 2 pAKT, phosphorylated AKT pulmonary hypertension right ventricle

DOI 10.1016/j.jacbts.2018.08.009

PMID 30623134

发布时间 2021-07-20

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JACC. Basic to translational science

2018年3卷6期

744-762页

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Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension.

JACC. Basic to translational science

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JACC. Basic to translational science

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Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension.

JACC. Basic to translational science

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JACC. Basic to translational science

相关期刊

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