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首页> Cell reports> Plasmodium Para-Aminobenzoate Synthesis and Salvage Resolve Avoidance of Folate Competition and Adaptation to Host Diet.

Plasmodium Para-Aminobenzoate Synthesis and Salvage Resolve Avoidance of Folate Competition and Adaptation to Host Diet.

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作者： Joachim Michael,Matz ^[1] ; Mutsumi,Watanabe ^[2] ; Mofolusho,Falade ^[3] ; Takayuki,Tohge ^[2] ; Rainer,Hoefgen ^[4] ; Kai,Matuschewski ^[5]

作者单位： Department of Molecular Parasitology, Institute of Biology, Humboldt University, 10115 Berlin, Germany; Parasitology Unit, Max Planck Institute of Infection Biology, 10117 Berlin, Germany. Electronic address: joachim.michael.matz@hu-berlin.de. ^[1] Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam-Golm, Germany; Nara Institute of Science and Technology, Graduate School of Biological Sciences, Plant Secondary Metabolism, 8916-5 Takayama-cho, Ikoma, Nara 630-0192, Japan. ^[2] University of Kentucky College of Pharmacy, Lexington, KY, USA. ^[3] Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam-Golm, Germany. ^[4] Department of Molecular Parasitology, Institute of Biology, Humboldt University, 10115 Berlin, Germany; Parasitology Unit, Max Planck Institute of Infection Biology, 10117 Berlin, Germany. ^[5]

关键词 ADCL ADCS Plasmodium aminodeoxychorismate lyase aminodeoxychorismate synthase folate malaria milk pABA para-aminobenzoic acid

主题词适应, 生理学(Adaptation, Physiological);动物(Animals);膳食(Diet);女(雌)性(Female);叶酸(Folic Acid);宿主与寄生虫关系(Host-Parasite Interactions);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);氧-酸裂合酶类(Oxo-Acid-Lyases);疟原虫属(Plasmodium);原虫蛋白质类(Protozoan Proteins);转氨酶类(Transaminases)

DOI 10.1016/j.celrep.2018.12.062

PMID 30625318

发布时间 2020-02-14

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