Targeting Protein-Protein Interactions of Tyrosine Phosphatases with Microarrayed Fragment Libraries Displayed on Phosphopeptide Substrate Scaffolds.

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第一作者： Megan,Hogan

第一单位： Molecular and Translational Sciences Division , United States Army Medical Research Institute of Infectious Diseases , Frederick , Maryland 21702 , United States.

作者： Megan,Hogan ^[1] ; Medhanit,Bahta ^[2] ; Kohei,Tsuji ^[2] ; Trung X,Nguyen ^[2] ; Scott,Cherry ^[3] ; George T,Lountos ^[3] ; Joseph E,Tropea ^[4] ; Bryan M,Zhao ^[3] ; Xue Zhi,Zhao ^[1] ; David S,Waugh ^[2] ; Terrence R,Burke ^[3] ; Robert G,Ulrich ^[2]

作者单位： Molecular and Translational Sciences Division , United States Army Medical Research Institute of Infectious Diseases , Frederick , Maryland 21702 , United States. ^[1] Chemical Biology Laboratory, Center for Cancer Research, National Institutes of Health , National Cancer Institute at Frederick , Frederick , Maryland 21702 , United States. ^[2] Macromolecular Crystallography Laboratory, National Cancer Institute , National Cancer Institute at Frederick , Frederick , Maryland 21702 , United States. ^[3] Basic Science Program , Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute , Frederick , Maryland 21702 , United States. ^[4]

关键词 aminooxy phosphopeptide catalytic assay fragment-based drug design kinetic assay microarray oxime-containing phosphopeptide protein tyrosine phosphatase substrate affinity screening surface plasmon resonance