Nucleosome spacing periodically modulates nucleosome chain folding and DNA topology in circular nucleosome arrays.

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作者： Mikhail V,Bass ^[1] ; Tatiana,Nikitina ^[2] ; Davood,Norouzi ^[3] ; Victor B,Zhurkin ^[3] ; Sergei A,Grigoryev ^[4]

作者单位： From the Department of Biochemistry and Molecular Biology, Penn State University College of Medicine, Hershey, Pennsylvania 17033. ^[1] Biological Faculty, Department of Molecular Biology, Lomonosov Moscow State University, 119192 Moscow, Russia, and. ^[2] Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892. ^[3] Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 zhurkin@nih.gov. ^[4] From the Department of Biochemistry and Molecular Biology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, sag17@psu.edu. ^[5]

关键词 DNA topology chromatin higher order structure chromatin structure computer modeling conformational simulation electron microscopy (EM)epigenetic regulation epigenetics gene regulation histone linker DNA nucleosome

主题词动物(Animals);鸡(Chickens);DNA(DNA);模型, 分子(Models, Molecular);核酸构象(Nucleic Acid Conformation);核小体(Nucleosomes);序列分析, DNA(Sequence Analysis, DNA)

DOI 10.1074/jbc.RA118.006412

PMID 30630950

发布时间 2021-02-05

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准确一般字义偏差语意偏离译文作用小提交