首页> European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences> Lack of inhibition of CYP2C8 by saroglitazar magnesium: In vivo assessment using montelukast, rosiglitazone, pioglitazone, repaglinide and paclitaxel as victim drugs in Wistar rats.

Lack of inhibition of CYP2C8 by saroglitazar magnesium: In vivo assessment using montelukast, rosiglitazone, pioglitazone, repaglinide and paclitaxel as victim drugs in Wistar rats.

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第一作者： Poonam,Giri

第一单位： Department of Drug Metabolism and Pharmacokinetics, Zydus Research Centre, Moraiya, Ahmadabad, Gujarat, India. Electronic address: poonamgiri@zyduscadila.com.

作者： Poonam,Giri ^[1] ; Prashant,Delvadia ^[2] ; Meera K,Ladani ^[2] ; Namrata,Prajapati ^[2] ; Lakshmikant,Gupta ^[2] ; Nirmal,Patel ^[2] ; Vipul,Joshi ^[2] ; Shyamkumar,Giri ^[2] ; Mukul R,Jain ^[3] ; Nuggehally R,Srinivas ^[2] ; Pankaj R,Patel ^[4]

作者单位： Department of Drug Metabolism and Pharmacokinetics, Zydus Research Centre, Moraiya, Ahmadabad, Gujarat, India. Electronic address: poonamgiri@zyduscadila.com. ^[1] Department of Drug Metabolism and Pharmacokinetics, Zydus Research Centre, Moraiya, Ahmadabad, Gujarat, India. ^[2] Department of Drug Metabolism and Pharmacokinetics, Zydus Research Centre, Moraiya, Ahmadabad, Gujarat, India; Department of Pharmacology, Zydus Research Centre, Moraiya, Ahmadabad, Gujarat, India. ^[3] Zydus Research Centre, Cadila Healthcare Ltd., Satellite cross road, Ahmadabad, Gujarat, India. ^[4]

关键词 CYP2C8 inhibition Clinically relevant DDI Coadministration Drug-drug interaction LC-MS/MS PPAR α? agonist Rat liver microsomes