Newcastle disease virus-like particles containing the Brucella BCSP31 protein induce dendritic cell activation and protect mice against virulent Brucella challenge.

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作者： Xiaohong,Xu ^[1] ; Zhuang,Ding ^[1] ; Jindou,Li ^[1] ; Jiaming,Liang ^[2] ; Zhaoyang,Bu ^[2] ; Jiaxin,Ding ^[1] ; Yanling,Yang ^[3] ; Xulong,Lang ^[2] ; Xinglong,Wang ^[2] ; Renfu,Yin ^[4] ; Jing,Qian ^[5]

作者单位： Laboratory of Infectious Diseases, College of Veterinary Medicine, Key Laboratory of Zoonosis Research, Ministry of Education, Jilin University, Changchun 130062, China. ^[1] Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Changchun 130122, China. ^[2] Institute of Special Wild Animal & Plant Science, Chinese Academy of Agricultural Sciences, Changchun 130122, China. ^[3] Laboratory of Infectious Diseases, College of Veterinary Medicine, Key Laboratory of Zoonosis Research, Ministry of Education, Jilin University, Changchun 130062, China. Electronic address: yin@jlu.edu.cn. ^[4] Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences / Key Laboratory for Veterinary Bio-Product Engineering, Ministry of Agriculture, Nanjing 210014, China. Electronic address: qjysb0110@126.com. ^[5]

关键词 Brucella BCSP31 protein Dendritic cell maturation Newcastle disease virus-like particles Protective efficacy Vaccine candidate