Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia.-论文-万方医学网

作者： Yuanyuan,Wang ^[1] ; Changsen,Bai ^[2] ; Yuxia,Ruan ^[1] ; Miao,Liu ^[1] ; Qiaoyun,Chu ^[1] ; Li,Qiu ^[3] ; Chuanzhen,Yang ^[1] ; Binghui,Li ^[3]

作者单位： Department of Cancer Cell Biology, Tianjin's Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, 300060, Tianjin, China. ^[1] Center of Diagnosis and Treatment of Breast Disease, the Affiliated Hospital of Qingdao University, 266071, Qingdao, China. ^[2] Department of Biochemistry and Molecular Biology, Capital Medical University, 100069, Beijing, China. ^[3] Department of Cancer Cell Biology, Tianjin's Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, 300060, Tianjin, China. bli@ccmu.edu.cn. ^[4] Department of Biochemistry and Molecular Biology, Capital Medical University, 100069, Beijing, China. bli@ccmu.edu.cn. ^[5] Advanced Innovation Center for Human Brain Protection, Capital Medical University, 100069, Beijing, China. bli@ccmu.edu.cn. ^[6]

主题词乙酰辅酶A(Acetyl Coenzyme A);氨(Ammonia);动物(Animals);碳(Carbon);细胞低氧(Cell Hypoxia);细胞系, 肿瘤(Cell Line, Tumor);细胞存活(Cell Survival);女(雌)性(Female);葡萄糖(Glucose);谷氨酰胺(Glutamine);HEK293细胞(HEK293 Cells);人类(Humans);乳酸(Lactic Acid);脂肪生成(Lipogenesis);代谢网络和途径(Metabolic Networks and Pathways);代谢组(Metabolome);代谢组学(Metabolomics);小鼠(Mice);小鼠, 裸(Mice, Nude);肿瘤(Neoplasms);氮(Nitrogen);核苷酸类(Nucleotides);乳清酸(Orotic Acid);肿瘤微环境(Tumor Microenvironment);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1038/s41467-018-08033-9

PMID 30643150

发布时间 2020-03-09

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Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia.

Nature communications

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Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia.

Nature communications

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Nature communications

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