换一批Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use.
第一作者：
Mengzhen,Liu
第一单位：
Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA.
作者：
Mengzhen,Liu [1]
;
Yu,Jiang [2]
;
Robbee,Wedow [3]
;
Yue,Li [4]
;
David M,Brazel [5]
;
Fang,Chen [2]
;
Gargi,Datta [1]
;
Jose,Davila-Velderrain [4]
;
Daniel,McGuire [2]
;
Chao,Tian [6]
;
Xiaowei,Zhan [7]
;
23andMe Research Team [8]
;
HUNT All-In Psychiatry [9]
;
Hélène,Choquet [10]
;
Anna R,Docherty [11]
;
Jessica D,Faul [11]
;
Johanna R,Foerster [12]
;
Lars G,Fritsche [13]
;
Maiken Elvestad,Gabrielsen [14]
;
Scott D,Gordon [15]
;
Jeffrey,Haessler [16]
;
Jouke-Jan,Hottenga [1]
;
Hongyan,Huang [17]
;
Seon-Kyeong,Jang [18]
;
Philip R,Jansen [19]
;
Yueh,Ling [20]
;
Reedik,Mägi [21]
;
Nana,Matoba [22]
;
George,McMahon [22]
;
Antonella,Mulas [23]
;
Valeria,Orrù [11]
;
Teemu,Palviainen [24]
;
Anita,Pandit [12]
;
Gunnar W,Reginsson [25]
;
Anne Heidi,Skogholt [21]
;
Jennifer A,Smith [16]
;
Amy E,Taylor [15]
;
Constance,Turman [1]
;
Gonneke,Willemsen [26]
;
Hannah,Young [11]
;
Kendra A,Young [27]
;
Gregory J M,Zajac [28]
;
Wei,Zhao [24]
;
Wei,Zhou [3]
;
Gyda,Bjornsdottir [11]
;
Jason D,Boardman [15]
;
Michael,Boehnke [14]
;
Dorret I,Boomsma [22]
;
Chu,Chen [29]
;
Francesco,Cucca [30]
;
Gareth E,Davies [31]
;
Charles B,Eaton [32]
;
Marissa A,Ehringer [22]
;
Tõnu,Esko [33]
;
Edoardo,Fiorillo [34]
;
Nathan A,Gillespie [19]
;
Daniel F,Gudbjartsson [35]
;
Toomas,Haller [36]
;
Kathleen Mullan,Harris [37]
;
Andrew C,Heath [38]
;
John K,Hewitt [26]
;
Ian B,Hickie [39]
;
John E,Hokanson [40]
;
Christian J,Hopfer [1]
;
David J,Hunter [41]
;
William G,Iacono [20]
;
Eric O,Johnson [27]
;
Yoichiro,Kamatani [37]
;
Sharon L R,Kardia [4]
;
Matthew C,Keller [14]
;
Manolis,Kellis [42]
;
Charles,Kooperberg [43]
;
Peter,Kraft [44]
;
Kenneth S,Krauter [45]
;
Markku,Laakso [23]
;
Penelope A,Lind [46]
;
Anu,Loukola [36]
;
Sharon M,Lutz [13]
;
Pamela A F,Madden [1]
;
Nicholas G,Martin [31]
;
Matt,McGue [45]
;
Matthew B,McQueen [19]
;
Sarah E,Medland [47]
;
Andres,Metspalu [48]
;
Karen L,Mohlke [49]
;
Jonas B,Nielsen [50]
;
Yukinori,Okada [51]
;
Ulrike,Peters [52]
;
Tinca J C,Polderman [50]
;
Danielle,Posthuma [53]
;
Alexander P,Reiner [54]
;
John P,Rice [55]
;
Eric,Rimm [56]
;
Richard J,Rose [37]
;
Valgerdur,Runarsdottir [57]
;
Michael C,Stallings [24]
;
Alena,Stančáková [8]
;
Hreinn,Stefansson [58]
;
Khanh K,Thai [56]
;
Hilary A,Tindle [59]
;
Thorarinn,Tyrfingsson [10]
;
Tamara L,Wall [8]
;
David R,Weir [13]
;
Constance,Weisner [60]
;
John B,Whitfield [8]
;
Bendik Slagsvold,Winsvold [61]
;
Jie,Yin [53]
;
Luisa,Zuccolo [62]
;
Laura J,Bierut [1]
;
Kristian,Hveem [63]
;
James J,Lee [64]
;
Marcus R,Munafò [65]
;
Nancy L,Saccone [66]
;
Cristen J,Willer [67]
;
Marilyn C,Cornelis [6]
;
Sean P,David [8]
;
David A,Hinds [68]
;
Eric,Jorgenson [31]
;
Jaakko,Kaprio [69]
;
Jerry A,Stitzel [24]
;
Kari,Stefansson [11]
;
Thorgeir E,Thorgeirsson [70]
;
Gonçalo,Abecasis [71]
;
Dajiang J,Liu ;
Scott,Vrieze
作者单位：
Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA.
[1]
Department of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA, USA.;Institute of Personalized Medicine, College of Medicine, Pennsylvania State University, Hershey, PA, USA.
[2]
Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.;Department of Sociology, University of Colorado Boulder, Boulder, CO, USA.;Institute of Behavioral Science, University of Colorado Boulder, Boulder, CO, USA.
[3]
Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA.;The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
[4]
Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.;Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA.;Interdisciplinary Quantitative Biology Graduate Group, University of Colorado Boulder, Boulder, CO, USA.
[5]
23andMe, Inc., Mountain View, CA, USA.
[6]
Quantitative Biomedical Research Center, Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.;Center for the Genetics of Host Defense, Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
[7]
Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
[8]
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.;Department of Psychiatry and Human Genetics, University of Utah, Salt Lake City, UT, USA.
[9]
Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
[10]
Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
[11]
K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
[12]
Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
[13]
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
[14]
Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
[15]
Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.;Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
[16]
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.;Department of Child and Adolescent Psychiatry, Erasmus MC Rotterdam, Rotterdam, the Netherlands.
[17]
Department of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA, USA.;Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA.
[18]
Estonian Genome Center, University of Tartu, Tartu, Estonia.
[19]
Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama City, Japan.
[20]
Department of Population Health Science, Bristol Medical School, Oakfield Grove, Bristol, UK.
[21]
Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Italy.
[22]
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
[23]
deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
[24]
Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.;Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
[25]
Department of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
[26]
Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
[27]
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
[28]
Avera Institute for Human Genetics, Sioux Falls, SD, USA.
[29]
Department of Family Medicine and Community Health, Alpert Medical School, Brown University, Providence, RI, USA.
[30]
Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.;Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
[31]
The Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Estonian Genome Center, University of Tartu, Tartu, Estonia.
[32]
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.;Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
[33]
deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.;School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.
[34]
Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.;Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
[35]
Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.
[36]
Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.;Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
[37]
Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
[38]
Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.;Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
[39]
Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.;Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.;Nuffield Department of Population Health, University of Oxford, Oxford, UK.
[40]
Fellows Program, RTI International, Research Triangle Park, NC, USA.
[41]
Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.;Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.;Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
[42]
Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.;Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA.
[43]
Department of Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.;Department of Medicine, Kuopio University Hospital, Kuopio, Finland.
[44]
Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
[45]
Department of Biostatistics and Bioinformatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
[46]
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
[47]
Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
[48]
Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama City, Japan.;Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
[49]
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.;Department of Epidemiology, University of Washington, Seattle, WA, USA.
[50]
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
[51]
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.;Department of Clinical Genetics, VU Medical Centre Amsterdam, Amsterdam, the Netherlands.
[52]
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
[53]
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.;Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
[54]
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.
[55]
SAA-National Center of Addiction Medicine, Vogur Hospital, Reykjavik, Iceland.
[56]
Department of Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
[57]
Department of Medicine, Vanderbilt University, Nashville, TN, USA.
[58]
Department of Psychiatry, University of California, San Diego, San Diego, CA, USA.
[59]
FORMI and Department of Neurology, Oslo University Hospital, Oslo, Norway.
[60]
Department of Population Health Science, Bristol Medical School, Oakfield Grove, Bristol, UK.;MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
[61]
K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.;HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway.;Department of Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway.
[62]
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.;UK Centre for Tobacco and Alcohol Studies, School of Psychological Science, University of Bristol, Bristol, UK.
[63]
Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
[64]
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.;Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.;Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
[65]
Department of Preventative Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
[66]
Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
[67]
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.;Department of Public Health, University of Helsinki, Helsinki, Finland.
[68]
deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.;Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
[69]
Department of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA, USA. dajiang.liu@psu.edu.;Institute of Personalized Medicine, College of Medicine, Pennsylvania State University, Hershey, PA, USA. dajiang.liu@psu.edu.
[70]
Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA. vrieze@umn.edu.
[71]
医学主题词
饮酒(Alcohol Drinking);女(雌)性(Female);遗传变异(Genetic Variation);全基因组关联研究(Genome-Wide Association Study);人类(Humans);男(雄)性(Male);中年人(Middle Aged);表型(Phenotype);危险(Risk);吸烟(Smoking);烟草对健康的危害(Tobacco Use Disorder)
DOI
10.1038/s41588-018-0307-5
PMID
30643251
发布时间
2025-05-30
- 浏览43
Nature genetics
Nature genetics
237-244页
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