换一批Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.
第一作者：
Richard,Karlsson Linnér
第一单位：
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands. r.karlssonlinner@vu.nl.;Erasmus University Rotterdam Institute for Behavior and Biology, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, the Netherlands. r.karlssonlinner@vu.nl.;Department of Economics, VU University Amsterdam, Amsterdam, the Netherlands. r.karlssonlinner@vu.nl.
作者：
Richard,Karlsson Linnér [1]
;
Pietro,Biroli [2]
;
Edward,Kong [3]
;
S Fleur W,Meddens [4]
;
Robbee,Wedow [5]
;
Mark Alan,Fontana [6]
;
Maël,Lebreton [7]
;
Stephen P,Tino [8]
;
Abdel,Abdellaoui [9]
;
Anke R,Hammerschlag [10]
;
Michel G,Nivard [9]
;
Aysu,Okbay [11]
;
Cornelius A,Rietveld [12]
;
Pascal N,Timshel [13]
;
Maciej,Trzaskowski [14]
;
Ronald de,Vlaming [4]
;
Christian L,Zünd [2]
;
Yanchun,Bao [15]
;
Laura,Buzdugan [16]
;
Ann H,Caplin [17]
;
Chia-Yen,Chen [18]
;
Peter,Eibich [19]
;
Pierre,Fontanillas [20]
;
Juan R,Gonzalez [21]
;
Peter K,Joshi [22]
;
Ville,Karhunen [23]
;
Aaron,Kleinman [20]
;
Remy Z,Levin [24]
;
Christina M,Lill [25]
;
Gerardus A,Meddens [26]
;
Gerard,Muntané [27]
;
Sandra,Sanchez-Roige [28]
;
Frank J van,Rooij [29]
;
Erdogan,Taskesen [10]
;
Yang,Wu [14]
;
Futao,Zhang [14]
;
23and Me Research Team [20]
;
eQTLgen Consortium [30]
;
International Cannabis Consortium [22]
;
Social Science Genetic Association Consortium [31]
;
Adam,Auton [9]
;
Jason D,Boardman [32]
;
David W,Clark [33]
;
Andrew,Conlin [34]
;
Conor C,Dolan [35]
;
Urs,Fischbacher [36]
;
Patrick J F,Groenen [29]
;
Kathleen Mullan,Harris [37]
;
Gregor,Hasler [38]
;
Albert,Hofman [39]
;
Mohammad A,Ikram [40]
;
Sonia,Jain [41]
;
Robert,Karlsson [23]
;
Ronald C,Kessler [42]
;
Maarten,Kooyman [43]
;
James,MacKillop [44]
;
Minna,Männikkö [15]
;
Carlos,Morcillo-Suarez [45]
;
Matthew B,McQueen [46]
;
Klaus M,Schmidt [47]
;
Melissa C,Smart [48]
;
Matthias,Sutter [49]
;
A Roy,Thurik [50]
;
André G,Uitterlinden [51]
;
Jon,White [9]
;
Harriet de,Wit [52]
;
Jian,Yang [2]
;
Lars,Bertram [20]
;
Dorret I,Boomsma [53]
;
Tõnu,Esko [15]
;
Ernst,Fehr [3]
;
David A,Hinds [38]
;
Magnus,Johannesson [54]
;
Meena,Kumari [55]
;
David,Laibson [56]
;
Patrik K E,Magnusson [13]
;
Michelle N,Meyer [57]
;
Arcadi,Navarro [58]
;
Abraham A,Palmer [59]
;
Tune H,Pers [31]
;
Danielle,Posthuma [29]
;
Daniel,Schunk [22]
;
Murray B,Stein [60]
;
Rauli,Svento [61]
;
Henning,Tiemeier [62]
;
Paul R H J,Timmers [63]
;
Patrick,Turley [64]
;
Robert J,Ursano [65]
;
Gert G,Wagner [66]
;
James F,Wilson [67]
;
Jacob,Gratten [68]
;
James J,Lee [69]
;
David,Cesarini ;
Daniel J,Benjamin ;
Philipp D,Koellinger ;
Jonathan P,Beauchamp
作者单位：
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands. r.karlssonlinner@vu.nl.;Erasmus University Rotterdam Institute for Behavior and Biology, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, the Netherlands. r.karlssonlinner@vu.nl.;Department of Economics, VU University Amsterdam, Amsterdam, the Netherlands. r.karlssonlinner@vu.nl.
[1]
Department of Economics, University of Zurich, Zurich, Switzerland.
[2]
Department of Economics, Harvard University, Cambridge, MA, USA.
[3]
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.;Erasmus University Rotterdam Institute for Behavior and Biology, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, the Netherlands.;Department of Economics, VU University Amsterdam, Amsterdam, the Netherlands.
[4]
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.;Analytic Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.;Department of Sociology, Harvard University, Cambridge, MA, USA.
[5]
Center for the Advancement of Value in Musculoskeletal Care, Hospital for Special Surgery, New York, NY, USA.;Department of Healthcare Policy and Research, Weill Cornell Medical College, Cornell University, New York, NY, USA.
[6]
Amsterdam School of Economics, University of Amsterdam, Amsterdam, the Netherlands.;Amsterdam Brain and Cognition, University of Amsterdam, Amsterdam, the Netherlands.
[7]
Department of Economics, University of Toronto, Toronto, Ontario, Canada.
[8]
Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
[9]
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.
[10]
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.;Department of Economics, VU University Amsterdam, Amsterdam, the Netherlands.
[11]
Erasmus University Rotterdam Institute for Behavior and Biology, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, the Netherlands.;Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, the Netherlands.;Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
[12]
Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.;Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
[13]
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
[14]
Institute for Social and Economic Research, University of Essex, Colchester, UK.
[15]
Seminar for Statistics, Department of Mathematics, ETH Zurich, Zurich, Switzerland.;Department of Economics, University of Zurich, Zurich, Switzerland.
[16]
Stuyvesant High School, New York, NY, USA.
[17]
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Analytic Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.;Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
[18]
Nuffield Department of Population Health, University of Oxford, Oxford, UK.;Socio-Economic Panel Study, DIW Berlin, Berlin, Germany.;Max Planck Institute for Demographic Research, Rostock, Germany.
[19]
Research, 23andMe, Inc., Mountain View, CA, USA.
[20]
Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.;Universitat Pompeu Fabra (UPF), Barcelona, Spain.;CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
[21]
Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland.
[22]
Center for Life Course Health Research, University of Oulu, Oulu, Finland.
[23]
Department of Economics, University of California San Diego, La Jolla, CA, USA.
[24]
Genetic and Molecular Epidemiology Group, Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics & Cardiogenetics, University of Lübeck, Lübeck, Germany.
[25]
Team Loyalty BV, Hoofddorp, the Netherlands.
[26]
Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.;Research Department, Hospital Universitari Institut Pere Mata, Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain.;Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM), Reus, Spain.
[27]
Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
[28]
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
[29]
Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.;Institute of Behavioral Science, University of Colorado Boulder, Boulder, CO, USA.;Department of Sociology, University of Colorado Boulder, Boulder, CO, USA.
[30]
Department of Economics and Finance, Oulu Business School, University of Oulu, Oulu, Finland.
[31]
Department of Economics, University of Konstanz, Konstanz, Germany.;Thurgau Institute of Economics, Kreuzlingen, Switzerland.
[32]
Erasmus University Rotterdam Institute for Behavior and Biology, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, the Netherlands.;Department of Econometrics, Erasmus University Rotterdam, Rotterdam, Rotterdam, the Netherlands.
[33]
Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.;Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
[34]
Unit of Psychiatry Research, University of Fribourg, Fribourg, Switzerland.
[35]
Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.;Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
[36]
Family Medicine and Public Health, University of California San Diego, La Jolla, CA, USA.
[37]
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
[38]
Department of Health Care Policy, Harvard Medical School, Boston, MA, USA.
[39]
SURFsara, Amsterdam, the Netherlands.
[40]
Peter Boris Centre for Addictions Research, McMaster University/St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.;Homewood Research Institute, Guelph, Ontario, Canada.
[41]
Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.
[42]
Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
[43]
Department of Economics, University of Munich, Munich, Germany.
[44]
Department of Economics, University of Cologne, Cologne, Germany.;Experimental Economics Group, Max Planck Institute for Research into Collective Goods, Bonn, Germany.;Department of Public Finance, University of Innsbruck, Innsbruck, Austria.
[45]
Erasmus University Rotterdam Institute for Behavior and Biology, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, the Netherlands.;Montpellier Business School, Montpellier, France.
[46]
Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, the Netherlands.
[47]
UCL Genetics Institute, Department of Genetics, Evolution and Environment, University College London, London, UK.
[48]
Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.
[49]
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.;Queensland Brain Institute, The University of Queensland, Brisbane, Australia.
[50]
Genetic and Molecular Epidemiology Group, Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics & Cardiogenetics, University of Lübeck, Lübeck, Germany.;Dept of Psychology, University of Olso, Oslo, Norway.;School of Public Health, Imperial College London, London, UK.
[51]
Estonian Genome Center, University of Tartu, Tartu, Estonia.
[52]
Department of Economics, Stockholm School of Economics, Stockholm, Sweden.
[53]
Center for Translational Bioethics and Health Care Policy, Geisinger Health System, Danville, PA, USA.
[54]
Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.;Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain.;Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain.
[55]
Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.;Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA.
[56]
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.;Department of Clinical Genetics, VU Medical Centre, Amsterdam, the Netherlands.
[57]
Department of Economics, Johannes Gutenberg University, Mainz, Germany.
[58]
Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.;Family Medicine and Public Health, University of California San Diego, La Jolla, CA, USA.
[59]
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Analytic Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.;Behavioral and Health Genomics Center, Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA.
[60]
Department of Psychiatry, Center for the Study of Traumatic Stress, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
[61]
Socio-Economic Panel Study, DIW Berlin, Berlin, Germany.;Max Planck Institute for Human Development, Berlin, Germany.
[62]
Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland.;MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland.
[63]
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.;Mater Medical Research Institute, Translational Research Institute, Brisbane, Australia.
[64]
Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA.
[65]
Department of Economics, New York University, New York, NY, USA.
[66]
Behavioral and Health Genomics Center, Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA.;Department of Economics, University of Southern California, Los Angeles, CA, USA.;National Bureau of Economic Research, Cambridge, MA, USA.
[67]
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.;Department of Economics, VU University Amsterdam, Amsterdam, the Netherlands.;German Institute for Economic Research, DIW Berlin, Berlin, Germany.
[68]
Department of Economics, University of Toronto, Toronto, Ontario, Canada. jonathan.pierre.beauchamp@gmail.com.
[69]
医学主题词
行为(Behavior);病例对照研究(Case-Control Studies);女(雌)性(Female);基因座(Genetic Loci);疾病遗传易感性(Genetic Predisposition to Disease);遗传学, 行为(Genetics, Behavioral);全基因组关联研究(Genome-Wide Association Study);基因型(Genotype);人类(Humans);男(雄)性(Male);多态性, 单核苷酸(Polymorphism, Single Nucleotide)
DOI
10.1038/s41588-018-0309-3
PMID
30643258
发布时间
2025-05-30
- 浏览23
Nature genetics
Nature genetics
245-257页
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