A genome-wide association study in individuals of African ancestry reveals the importance of the Duffy-null genotype in the assessment of clozapine-related neutropenia.
第一作者:
Sophie E,Legge
第一单位:
MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK.
作者:
主题词
等位基因(Alleles);抗精神病药(Antipsychotic Agents);氯氮平(Clozapine);Duffy血型系统(Duffy Blood-Group System);女(雌)性(Female);疾病遗传易感性(Genetic Predisposition to Disease);全基因组关联研究(Genome-Wide Association Study);人类(Humans);男(雄)性(Male);中性粒细胞减少(Neutropenia);中性白细胞(Neutrophils);多态性, 单核苷酸(Polymorphism, Single Nucleotide);受体, 细胞表面(Receptors, Cell Surface);危险因素(Risk Factors);精神分裂症(Schizophrenia)
DOI
10.1038/s41380-018-0335-7
PMID
30647433
发布时间
2022-12-07
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Molecular psychiatry
328-337页
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