HIF-1α metabolically controls collagen synthesis and modification in chondrocytes.

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第一作者： Steve,Stegen

第一单位： Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.

作者： Steve,Stegen ^[1] ; Kjell,Laperre ^[1] ; Guy,Eelen ^[2] ; Gianmarco,Rinaldi ^[3] ; Peter,Fraisl ^[2] ; Sophie,Torrekens ^[1] ; Riet,Van Looveren ^[1] ; Shauni,Loopmans ^[1] ; Geert,Bultynck ^[4] ; Stefan,Vinckier ^[2] ; Filip,Meersman ^[5] ; Patrick H,Maxwell ^[6] ; Jyoti,Rai ^[7] ; MaryAnn,Weis ^[7] ; David R,Eyre ^[7] ; Bart,Ghesquière ^[8] ; Sarah-Maria,Fendt ^[3] ; Peter,Carmeliet ^[9] ; Geert,Carmeliet ^[10]

作者单位： Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium. ^[1] Laboratory of Angiogenesis and Vascular Biology, VIB Center for Cancer Biology, VIB, Leuven, Belgium.;Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, Leuven, Belgium. ^[2] Laboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium.;Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, Leuven, Belgium. ^[3] Laboratory of Molecular and Cellular Signalling, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium. ^[4] Molecular and Nanomaterials, KU Leuven, Leuven, Belgium. ^[5] Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK. ^[6] Department of Orthopaedics, University of Washington, Seattle, WA, USA. ^[7] Metabolomics Expertise Center, Department of Oncology, KU Leuven/VIB Center for Cancer Biology Leuven, Leuven, Belgium. ^[8] Laboratory of Angiogenesis and Vascular Biology, VIB Center for Cancer Biology, VIB, Leuven, Belgium.;Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, Leuven, Belgium.;State Key Laboratory of Ophtalmology, Zhongshan Ophtalmic Center, Sun Yat-Sen University, Guangzhou, China. ^[9] Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium. geert.carmeliet@kuleuven.be. ^[10]