Synthesis and antitubercular evaluation of reduced lipophilic imidazo[1,2-a]pyridine-3-carboxamide derivatives.

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作者： Hongjian,Wang ^[1] ; Apeng,Wang ^[1] ; Jian,Gu ^[2] ; Lei,Fu ^[3] ; Kai,Lv ^[1] ; Chao,Ma ^[1] ; Zeyu,Tao ^[1] ; Bin,Wang ^[3] ; Mingliang,Liu ^[4] ; Huiyuan,Guo ^[1] ; Yu,Lu ^[5]

作者单位： Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. ^[1] College of Pharmacy, Southwest Minzu University, Chengdu, 610041, China. ^[2] Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Department of Pharmacology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, Beijing, 100149, China. ^[3] Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. Electronic address: lmllyx@126.com. ^[4] Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Department of Pharmacology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, Beijing, 100149, China. Electronic address: luyu4876@hotmail.com. ^[5]

关键词 Antitubercular agents Pharmacokinetics imidazo[1,2-a]pyridine carboxamides structure?activity relationships