PIM inhibitor SMI-4a induces cell apoptosis in B-cell acute lymphocytic leukemia cells via the HO-1-mediated JAK2/STAT3 pathway.
第一作者:
Xingyi,Kuang
第一单位:
Department of Hematology, The Affiliated Hospital of Guizhou Medical University, Guiyang, PR China; Guizhou Province Hematopoietic Stem Cell Transplantation Center, The Affiliated Hospital of Guizhou Medical University, Guiyang, PR China; Key Laboratory of Hematological Disease Diagnostic Treat Centre of Guizhou Province, Guiyang, PR China.
作者:
主题词
青少年(Adolescent);成年人(Adult);动物(Animals);细胞凋亡(Apoptosis);苄烯化合物(Benzylidene Compounds);印迹法, 蛋白质(Blotting, Western);儿童(Child);儿童, 学龄前(Child, Preschool);女(雌)性(Female);流式细胞术(Flow Cytometry);血红素加氧酶-1(Heme Oxygenase-1);人类(Humans);婴儿(Infant);Janus激酶2(Janus Kinase 2);小鼠, 近交NOD(Mice, Inbred NOD);中年人(Middle Aged);肿瘤移植(Neoplasm Transplantation);前体B细胞淋巴母细胞白血病淋巴瘤(Precursor B-Cell Lymphoblastic Leukemia-Lymphoma);STAT3转录因子(STAT3 Transcription Factor);信号传导(Signal Transduction);噻唑烷二酮类(Thiazolidinediones);青年人(Young Adult)
DOI
10.1016/j.lfs.2019.01.022
PMID
30658101
发布时间
2021-12-04
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Life sciences
248-256页
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