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Structural and In Vitro Functional Comparability Analysis of Altebrel™, a Proposed Etanercept Biosimilar: Focus on Primary Sequence and Glycosylation.

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第一作者： Ramin,Fazel

第一单位： Department of Biotechnology, College of Science, The University of Tehran, 1417864311 Tehran, Iran. Ramin.Fazel@gmail.com.;Mass Spectrometric Proteomics, Institute of Clinical Chemistry and Laboratory Medicine, Campus Forschung, N27 Raum 00.008, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany. Ramin.Fazel@gmail.com.

作者： Ramin,Fazel ^[1] ; Yudong,Guan ^[2] ; Behrouz,Vaziri ^[3] ; Christoph,Krisp ^[4] ; Laura,Heikaus ^[5] ; Amirhossein,Saadati ^[6] ; Siti,Nurul Hidayah ^[7] ; Manasi,Gaikwad ^[8] ; Hartmut,Schlüter ^[9]

作者单位： Department of Biotechnology, College of Science, The University of Tehran, 1417864311 Tehran, Iran. Ramin.Fazel@gmail.com.;Mass Spectrometric Proteomics, Institute of Clinical Chemistry and Laboratory Medicine, Campus Forschung, N27 Raum 00.008, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany. Ramin.Fazel@gmail.com. ^[1] Mass Spectrometric Proteomics, Institute of Clinical Chemistry and Laboratory Medicine, Campus Forschung, N27 Raum 00.008, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany. y.guan@uke.de. ^[2] Biotechnology Research Center, Pasteur Institute of Iran, 1316943551 Tehran, Iran. Behrouz-vaziri@pasteur.ac.ir. ^[3] Mass Spectrometric Proteomics, Institute of Clinical Chemistry and Laboratory Medicine, Campus Forschung, N27 Raum 00.008, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany. c.krisp@uke.de. ^[4] Mass Spectrometric Proteomics, Institute of Clinical Chemistry and Laboratory Medicine, Campus Forschung, N27 Raum 00.008, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany. l.heikaus@uke.de. ^[5] AryoGen Pharmed, Cross Tajbakhsh Street, 24th Kilometer Makhsous, Tehran, Iran. saadatirada@aryogen.com. ^[6] Mass Spectrometric Proteomics, Institute of Clinical Chemistry and Laboratory Medicine, Campus Forschung, N27 Raum 00.008, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany. s.hidayah@uke.de. ^[7] Mass Spectrometric Proteomics, Institute of Clinical Chemistry and Laboratory Medicine, Campus Forschung, N27 Raum 00.008, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany. m.gaikwad@uke.de. ^[8] Mass Spectrometric Proteomics, Institute of Clinical Chemistry and Laboratory Medicine, Campus Forschung, N27 Raum 00.008, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany. hschluet@uke.de. ^[9]

关键词 amidation biopharmaceutics biosimilar comparability study etanercept functional assay glycosylation mass spectrometry oxidation permethylation

DOI 10.3390/ph12010014

PMID 30658444

发布时间 2020-09-30

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