ACOT12-Dependent Alteration of Acetyl-CoA Drives Hepatocellular Carcinoma Metastasis by Epigenetic Induction of Epithelial-Mesenchymal Transition.

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第一作者： Ming,Lu

第一单位： Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute, Fudan University, 12 Urumqi Road (M), Shanghai 200040, China. Electronic address: luming@huashan.org.cn.

作者： Ming,Lu ^[1] ; Wen-Wei,Zhu ^[2] ; Xuan,Wang ^[2] ; Jing-Jie,Tang ^[3] ; Kai-Li,Zhang ^[4] ; Guang-Yang,Yu ^[4] ; Wei-Qing,Shao ^[2] ; Zhi-Fei,Lin ^[2] ; Sheng-Hao,Wang ^[2] ; Lu,Lu ^[2] ; Jian,Zhou ^[5] ; Lian-Xin,Wang ^[5] ; Hu-Liang,Jia ^[2] ; Qiong-Zhu,Dong ^[4] ; Jin-Hong,Chen ^[2] ; Jian-Quan,Lu ^[5] ; Lun-Xiu,Qin ^[6]

作者单位： Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute, Fudan University, 12 Urumqi Road (M), Shanghai 200040, China. Electronic address: luming@huashan.org.cn. ^[1] Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute, Fudan University, 12 Urumqi Road (M), Shanghai 200040, China. ^[2] State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China. ^[3] Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute, Fudan University, 12 Urumqi Road (M), Shanghai 200040, China; Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China. ^[4] Qidong People's Hospital, Jiangsu 226299, China. ^[5] Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute, Fudan University, 12 Urumqi Road (M), Shanghai 200040, China; Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China. Electronic address: qinlx@fudan.edu.cn. ^[6]

关键词 ACOT12 TWIST2 acetyl-CoA cancer metastasis epithelial-mesenchymal transition hepatocellular carcinoma histone acetylation