Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions.-论文-万方医学网

第一作者： Vitor H,Teixeira

第一单位： Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK.

作者： Vitor H,Teixeira ^[1] ; Christodoulos P,Pipinikas ^[1] ; Adam,Pennycuick ^[2] ; Henry,Lee-Six ^[1] ; Deepak,Chandrasekharan ^[3] ; Jennifer,Beane ^[1] ; Tiffany J,Morris ^[4] ; Anna,Karpathakis ^[2] ; Andrew,Feber ^[2] ; Charles E,Breeze ^[2] ; Paschalis,Ntolios ^[2] ; Robert E,Hynds ^[1] ; Mary,Falzon ^[1] ; Arrigo,Capitanio ^[5] ; Bernadette,Carroll ^[6] ; Pascal F,Durrenberger ^[7] ; Georgia,Hardavella ^[7] ; James M,Brown ^[8] ; Andy G,Lynch ^[9] ; Henry,Farmery ^[8] ; Dirk S,Paul ^[1] ; Rachel C,Chambers ^[10] ; Nicholas,McGranahan ^[11] ; Neal,Navani ^[10] ; Ricky M,Thakrar ^[2] ; Charles,Swanton ^[9] ; Stephan,Beck ^[5] ; Phillip Jeremy,George ^[1] ; Avrum,Spira ^[8] ; Peter J,Campbell ^[1] ; Christina,Thirlwell ^[8] ; Sam M,Janes ^[5]

作者单位： Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK. ^[1] Research Department of Cancer Biology and Medical Genomics Laboratory, UCL Cancer Institute, University College London, London, UK. ^[2] The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK. ^[3] Department of Medicine, Boston University School of Medicine, Boston, MA, USA. ^[4] CRUK Lung Cancer Centre of Excellence, UCL Cancer Institute, London, UK. ^[5] Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK. ^[6] Department of Pathology, University College London Hospitals NHS Trust, London, UK. ^[7] Department of Thoracic Medicine, University College London Hospital, London, UK. ^[8] Center for Inflammation and Tissue Repair, UCL Respiratory, University College London, London, UK. ^[9] Computational Biology and Statistics Laboratory, Cancer Research UK Cambridge Institute, Cambridge, UK. ^[10] School of Medicine/School of Mathematics and Statistics, University of St Andrews, St Andrews, UK. ^[11] Johnson and Johnson Innovation, Cambridge, MA, USA. ^[12] Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK. s.janes@ucl.ac.uk. ^[13] Department of Thoracic Medicine, University College London Hospital, London, UK. s.janes@ucl.ac.uk. ^[14]

主题词成年人(Adult);老年人(Aged);老年人, 80以上(Aged, 80 and over);原位癌(Carcinoma in Situ);癌, 鳞状细胞(Carcinoma, Squamous Cell);染色体不稳定性(Chromosomal Instability);队列研究(Cohort Studies);DNA拷贝数变异(DNA Copy Number Variations);DNA甲基化(DNA Methylation);疾病恶化(Disease Progression);表观基因组学(Epigenomics);女(雌)性(Female);基因表达谱(Gene Expression Profiling);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);基因组学(Genomics);人类(Humans);纵向研究(Longitudinal Studies);肺肿瘤(Lung Neoplasms);男(雄)性(Male);中年人(Middle Aged);突变(Mutation)

DOI 10.1038/s41591-018-0323-0

PMID 30664780

发布时间 2024-02-10

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Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions.

Nature medicine

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Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions.

Nature medicine

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Nature medicine

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