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首页> Clinical pharmacology and therapeutics> Interindividual and Regional Variability in Drug Transporter Abundance at the Human Blood-Brain Barrier Measured by Quantitative Targeted Proteomics.

Interindividual and Regional Variability in Drug Transporter Abundance at the Human Blood-Brain Barrier Measured by Quantitative Targeted Proteomics.

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第一作者： Sarah,Billington

第一单位： Department of Pharmaceutics, University of Washington, Seattle, Washington, USA.

作者： Sarah,Billington ^[1] ; Laurent,Salphati ^[2] ; Cornelis E C A,Hop ^[2] ; Xiaoyan,Chu ^[3] ; Raymond,Evers ^[3] ; Doug,Burdette ^[4] ; Christopher,Rowbottom ^[4] ; Yurong,Lai ^[5] ; Guangqing,Xiao ^[6] ; W Griffith,Humphreys ^[7] ; Tot Bui,Nguyen ^[1] ; Bhagwat,Prasad ^[1] ; Jashvant D,Unadkat ^[1]

作者单位： Department of Pharmaceutics, University of Washington, Seattle, Washington, USA. ^[1] Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California, USA. ^[2] Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Kenilworth, New Jersey, USA. ^[3] DMPK, Biogen, Cambridge, Massachusetts, USA. ^[4] Department of Drug Metabolism and Pharmacokinetics, Gilead Sciences, Inc., Foster City, California, USA. ^[5] Department of Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, USA. ^[6] Bristol-Myers Squibb Company, Princeton, New Jersey, USA. ^[7]

主题词 ATP结合匣式转运子(ATP-Binding Cassette Transporters);成年人(Adult);血脑屏障(Blood-Brain Barrier);脑(Brain);尸体(Cadaver);内皮细胞(Endothelial Cells);女(雌)性(Female);人类(Humans);男(雄)性(Male);膜转运蛋白质类(Membrane Transport Proteins);中年人(Middle Aged);有机阴离子转运子(Organic Anion Transporters);蛋白质组学(Proteomics)

DOI 10.1002/cpt.1373

PMID 30673124

发布时间 2020-03-30

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Clinical pharmacology and therapeutics

Clinical pharmacology and therapeutics

2019年106卷1期

228-237页

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