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Transcriptional Heterogeneity in Naive and Primed Human Pluripotent Stem Cells at Single-Cell Resolution.

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第一作者： Tobias,Messmer

第一单位： Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK; Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany.

作者： Tobias,Messmer ^[1] ; Ferdinand,von Meyenn ^[2] ; Aurora,Savino ^[3] ; Fátima,Santos ^[3] ; Hisham,Mohammed ^[3] ; Aaron Tin Long,Lun ^[4] ; John C,Marioni ^[5] ; Wolf,Reik ^[6]

作者单位： Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK; Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany. ^[1] Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK; Department of Medical and Molecular Genetics, King's College London, London SE1 9RT, UK. ^[2] Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK. ^[3] Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK. Electronic address: aaron.lun@cruk.cam.ac.uk. ^[4] Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK; EMBL European Bioinformatics Institute, Wellcome Genome Campus, Hinxton CB10 1SD, UK. Electronic address: marioni@ebi.ac.uk. ^[5] Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK. Electronic address: wolf.reik@babraham.ac.uk. ^[6]

关键词 early embryonic development evolution heterogeneity human embryonic stem cells naive pluripotency primed single-cell RNA-seq

医学主题词细胞系(Cell Line);后成说, 遗传(Epigenesis, Genetic);人类(Humans);序列分析, RNA(Sequence Analysis, RNA);单细胞分析(Single-Cell Analysis);转录, 遗传(Transcription, Genetic)

DOI 10.1016/j.celrep.2018.12.099

PMID 30673604

发布时间 2025-05-30

基金项目

MR/S005536/1/MRC_/Medical Research Council/United Kingdom 17197/CRUK_/Cancer Research UK/United Kingdom 095645/Z/11/Z/WT_/Wellcome Trust/United Kingdom MR/R015724/1/MRC_/Medical Research Council/United Kingdom BB/K010867/1/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom WT_/Wellcome Trust/United Kingdom

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