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LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML.

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第一作者： Jessica,Barth

第一单位： Department of Medicine II, Hematology/Oncology, Goethe University, Frankfurt/Main, Germany.;German Cancer Consortium (DKTK), Frankfurt, Germany.;German Cancer Research Center (DKFZ), Heidelberg, Germany.

作者： Jessica,Barth ^[1] ; Khalil,Abou-El-Ardat ^[1] ; Denis,Dalic ^[2] ; Nina,Kurrle ^[2] ; Anna-Maria,Maier ^[2] ; Sebastian,Mohr ^[2] ; Judith,Schütte ^[3] ; Lothar,Vassen ^[3] ; Gabriele,Greve ^[4] ; Johannes,Schulz-Fincke ^[5] ; Martin,Schmitt ^[6] ; Milica,Tosic ^[7] ; Eric,Metzger ^[7] ; Gesine,Bug ^[1] ; Cyrus,Khandanpour ^[3] ; Sebastian A,Wagner ^[1] ; Michael,Lübbert ^[4] ; Manfred,Jung ^[5] ; Hubert,Serve ^[1] ; Roland,Schüle ^[8] ; Tobias,Berg ^[9]

作者单位： Department of Medicine II, Hematology/Oncology, Goethe University, Frankfurt/Main, Germany.;German Cancer Consortium (DKTK), Frankfurt, Germany.;German Cancer Research Center (DKFZ), Heidelberg, Germany. ^[1] Department of Medicine II, Hematology/Oncology, Goethe University, Frankfurt/Main, Germany. ^[2] Department of Medicine A, University Hospital Muenster, Muenster, Germany. ^[3] German Cancer Research Center (DKFZ), Heidelberg, Germany.;German Cancer Consortium (DKTK), Freiburg, Germany.;Department of Medicine I, Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University of Freiburg Medical Center, Freiburg, Germany. ^[4] German Cancer Research Center (DKFZ), Heidelberg, Germany.;German Cancer Consortium (DKTK), Freiburg, Germany.;Institute of Pharmaceutical Sciences, University of Freiburg, Freiburg, Germany. ^[5] Institute of Pharmaceutical Sciences, University of Freiburg, Freiburg, Germany. ^[6] Department of Urology and Center for Clinical Research, University of Freiburg Medical Center, Freiburg, Germany. ^[7] Department of Urology and Center for Clinical Research, University of Freiburg Medical Center, Freiburg, Germany.;BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-University, 79104, Freiburg, Germany. ^[8] Department of Medicine II, Hematology/Oncology, Goethe University, Frankfurt/Main, Germany. tobias.berg@kgu.de.;German Cancer Consortium (DKTK), Frankfurt, Germany. tobias.berg@kgu.de.;German Cancer Research Center (DKFZ), Heidelberg, Germany. tobias.berg@kgu.de. ^[9]