Putative Mechanisms Underlying High Inhibitory Activities of Bimodular DNA Aptamers to Thrombin.

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作者： Elena G,Zavyalova ^[1] ; Valeriia A,Legatova ^[2] ; Rugiya Sh,Alieva ^[3] ; Arthur O,Zalevsky ^[4] ; Vadim N,Tashlitsky ^[5] ; Alexander M,Arutyunyan ^[6] ; Alexey M,Kopylov ^[7]

作者单位： Chemistry Department, Lomonosov Moscow State University, 119991 Moscow, Russia. zlenka2006@gmail.com. ^[1] Chemistry Department, Lomonosov Moscow State University, 119991 Moscow, Russia. lera000006@gmail.com. ^[2] Chemistry Department, Lomonosov Moscow State University, 119991 Moscow, Russia. ruqiwa_eva@mail.ru. ^[3] Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119234 Moscow, Russia. aozalevsky@gmail.com. ^[4] Chemistry Department, Lomonosov Moscow State University, 119991 Moscow, Russia. tashlitsky@belozersky.msu.ru. ^[5] Belozersky Research Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia. alarut@genebee.msu.ru. ^[6] Chemistry Department, Lomonosov Moscow State University, 119991 Moscow, Russia. kopylov.alex@gmail.com. ^[7]

关键词 DNA aptamer G-quadruplex conformational polymorphism structure–activity relationship thermodynamics thrombin

主题词适体, 核苷(Aptamers, Nucleotide);寡核苷酸类(Oligonucleotides);蛋白质解折叠(Protein Unfolding);丝氨酸蛋白酶抑制剂(Serine Proteinase Inhibitors);热力学(Thermodynamics);凝血酶(Thrombin)

DOI 10.3390/biom9020041

PMID 30682825

发布时间 2020-03-09

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Biomolecules

2019年9卷2期

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Putative Mechanisms Underlying High Inhibitory Activities of Bimodular DNA Aptamers to Thrombin.

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Putative Mechanisms Underlying High Inhibitory Activities of Bimodular DNA Aptamers to Thrombin.

Biomolecules

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Biomolecules

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