Combinations of two drugs among NS3/4A inhibitors, NS5B inhibitors and non-selective antiviral agents are effective for hepatitis C virus with NS5A-P32 deletion in humanized-liver mice.-论文-万方医学网

第一作者： Akira,Doi

第一单位： Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

作者： Akira,Doi ^[1] ; Hayato,Hikita ^[1] ; Yugo,Kai ^[1] ; Yuki,Tahata ^[1] ; Yoshinobu,Saito ^[1] ; Tasuku,Nakabori ^[1] ; Ryoko,Yamada ^[1] ; Takahiro,Kodama ^[1] ; Ryotaro,Sakamori ^[1] ; Asako,Murayama ^[2] ; Sayuri,Nitta ^[3] ; Yasuhiro,Asahina ^[3] ; Hiroshi,Suemizu ^[4] ; Tomohide,Tatsumi ^[5] ; Takanobu,Kato ^[1] ; Tetsuo,Takehara ^[2]

作者单位： Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. ^[1] Department of Virology II, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan. ^[2] Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, 4-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan. ^[3] Department of Liver Disease Control, Tokyo Medical and Dental University, 4-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan. ^[4] Department of Laboratory Animal Research, Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki, 210-0821, Japan. ^[5] Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. takehara@gh.med.osaka-u.ac.jp. ^[6]

主题词老年人(Aged);动物(Animals);抗病毒药(Antiviral Agents);苯咪唑类(Benzimidazoles);苯呋喃类(Benzofurans);氨甲酸酯类(Carbamates);细胞系(Cell Line);嵌合体(Chimera);抗药性, 病毒(Drug Resistance, Viral);药物疗法, 联合(Drug Therapy, Combination);芴类(Fluorenes);肝炎病毒属(Hepacivirus);丙型肝炎(Hepatitis C);肝细胞(Hepatocytes);人类(Humans);咪唑类(Imidazoles);干扰素α(Interferon-alpha);男(雄)性(Male);小鼠(Mice);中年人(Middle Aged);聚乙烯二醇类(Polyethylene Glycols);吡咯烷类(Pyrrolidines);重组蛋白质类(Recombinant Proteins);利巴韦林(Ribavirin);序列缺失(Sequence Deletion);丝氨酸蛋白酶类(Serine Proteases);缬氨酸(Valine);病毒非结构蛋白质类(Viral Nonstructural Proteins)

DOI 10.1007/s00535-018-01541-x

PMID 30684016

发布时间 2022-09-09

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Combinations of two drugs among NS3/4A inhibitors, NS5B inhibitors and non-selective antiviral agents are effective for hepatitis C virus with NS5A-P32 deletion in humanized-liver mice.

Journal of gastroenterology

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Journal of gastroenterology

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Combinations of two drugs among NS3/4A inhibitors, NS5B inhibitors and non-selective antiviral agents are effective for hepatitis C virus with NS5A-P32 deletion in humanized-liver mice.

Journal of gastroenterology

相似文献

Journal of gastroenterology

相关期刊

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