Cannabinoid type-1 receptor blockade restores neurological phenotypes in two models for Down syndrome.

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第一作者： Alba,Navarro-Romero

第一单位： Laboratory of Neuropharmacology-NeuroPhar, Department of Experimental and Health Sciences, University Pompeu Fabra, 08003 Barcelona, Spain.

作者： Alba,Navarro-Romero ^[1] ; Anna,Vázquez-Oliver ^[1] ; Maria,Gomis-González ^[1] ; Carlos,Garzón-Montesinos ^[2] ; Rafael,Falcón-Moya ^[2] ; Antoni,Pastor ^[3] ; Elena,Martín-García ^[4] ; Nieves,Pizarro ^[5] ; Arnau,Busquets-Garcia ^[1] ; Jean-Michel,Revest ^[6] ; Pier-Vincenzo,Piazza ^[6] ; Fátima,Bosch ^[7] ; Mara,Dierssen ^[8] ; Rafael,de la Torre ^[3] ; Antonio,Rodríguez-Moreno ^[2] ; Rafael,Maldonado ^[1] ; Andrés,Ozaita ^[9]

作者单位： Laboratory of Neuropharmacology-NeuroPhar, Department of Experimental and Health Sciences, University Pompeu Fabra, 08003 Barcelona, Spain. ^[1] Laboratory of Cellular Neuroscience and Plasticity, Department of Physiology, Anatomy and Cell Biology, University Pablo de Olavide, Ctra Utrera km. 1, 41013 Seville, Spain. ^[2] Integrative Pharmacology and Systems Neuroscience Research Group, Hospital del Mar Medical Research Institute, 08003 Barcelona, Spain; CIBER Pathophysiology of Obesity and Nutrition, Institute of Health Carlos III, 28029 Madrid, Spain. ^[3] Laboratory of Neuropharmacology-NeuroPhar, Department of Experimental and Health Sciences, University Pompeu Fabra, 08003 Barcelona, Spain; Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, Spain. ^[4] Integrative Pharmacology and Systems Neuroscience Research Group, Hospital del Mar Medical Research Institute, 08003 Barcelona, Spain. ^[5] INSERM U1215, Neurocentre Magendie, Physiopathology and Therapeutic Approaches of Stress-Related Diseases, 33077 Bordeaux, France. ^[6] Center of Animal Biotechnology and Gene Therapy (CBATEG), Spain; Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain; CIBER Diabetes and Associated Metabolic Disorders (CIBERDEM), 08017 Madrid, Spain. ^[7] Cellular & Systems Neurobiology, Systems Biology Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003 Barcelona, Spain; CIBER Rare Disorders (CIBERER), Spain; Hospital del Mar Medical Research Institute, 08003 Barcelona, Spain. ^[8] Laboratory of Neuropharmacology-NeuroPhar, Department of Experimental and Health Sciences, University Pompeu Fabra, 08003 Barcelona, Spain. Electronic address: andres.ozaita@upf.edu. ^[9]

关键词 Cannabinoid receptor type-1 Cognitive deficits Down syndrome Endocannabinoid system Hippocampus Intellectual disability