Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Cancers.-论文-万方医学网

第一作者： Hideaki,Ogiwara

第一单位： Division of Genome Biology, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. Electronic address: hogiwara@ncc.go.jp.

作者： Hideaki,Ogiwara ^[1] ; Kazuaki,Takahashi ^[2] ; Mariko,Sasaki ^[3] ; Takafumi,Kuroda ^[2] ; Hiroshi,Yoshida ^[4] ; Reiko,Watanabe ^[4] ; Ami,Maruyama ^[5] ; Hideki,Makinoshima ^[6] ; Fumiko,Chiwaki ^[7] ; Hiroki,Sasaki ^[7] ; Tomoyasu,Kato ^[8] ; Aikou,Okamoto ^[9] ; Takashi,Kohno ^[10]

作者单位： Division of Genome Biology, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. Electronic address: hogiwara@ncc.go.jp. ^[1] Division of Genome Biology, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan; Department of Obstetrics and Gynecology, The Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, Japan. ^[2] Division of Genome Biology, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan; Molecular Oncology, The Jikei University Graduate School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, Japan. ^[3] Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. ^[4] Tsuruoka Metabolomics Laboratory, National Cancer Center, Tsuruoka, Yamagata 997-0052, Japan; Shonai Regional Industry Promotion Center, Tsuruoka, Yamagata 997-0015, Japan. ^[5] Tsuruoka Metabolomics Laboratory, National Cancer Center, Tsuruoka, Yamagata 997-0052, Japan. ^[6] Department of Translational Oncology, Fundamental Innovative Oncology Core Center, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. ^[7] Department of Gynecology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. ^[8] Department of Obstetrics and Gynecology, The Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, Japan. ^[9] Division of Genome Biology, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan; Molecular Oncology, The Jikei University Graduate School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, Japan. Electronic address: tkkohno@ncc.go.jp. ^[10]

主题词氨基酸转运系统y+(Amino Acid Transport System y+);动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);DNA结合蛋白质类(DNA-Binding Proteins);酶抑制剂(Enzyme Inhibitors);女(雌)性(Female);谷氨酸-半胱氨酸连接酶(Glutamate-Cysteine Ligase);谷胱甘肽(Glutathione);HCT116细胞(HCT116 Cells);人类(Humans);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 裸(Mice, Nude);分子靶向治疗(Molecular Targeted Therapy);核蛋白质类(Nuclear Proteins);卵巢肿瘤(Ovarian Neoplasms);氧化性应激(Oxidative Stress);奎宁环类(Quinuclidines);转录因子(Transcription Factors);肿瘤细胞, 培养的(Tumor Cells, Cultured);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1016/j.ccell.2018.12.009

PMID 30686770

发布时间 2021-11-24

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Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Cancers.

Cancer cell

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Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Cancers.

Cancer cell

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Cancer cell

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