换一批
换一批3-Hydroxyisoindolin-1-one derivates: Synthesis by palladium-catalyzed CH activation as BRD4 inhibitors against human acute myeloid leukemia (AML) cells.
作者：
主题词
抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);催化作用(Catalysis);细胞周期蛋白质类(Cell Cycle Proteins);细胞增殖(Cell Proliferation);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);人类(Humans);白血病, 髓样, 急性(Leukemia, Myeloid, Acute);分子结构(Molecular Structure);钯(Palladium);苯邻二甲酰亚胺类(Phthalimides);构效关系(Structure-Activity Relationship);转录因子(Transcription Factors);肿瘤细胞, 培养的(Tumor Cells, Cultured)
DOI
10.1016/j.bioorg.2019.01.034
PMID
30690335
发布时间
2020-03-31
- 浏览15
Bioorganic chemistry
119-125页
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