A phase 1 dose escalation study of the oncolytic adenovirus enadenotucirev, administered intravenously to patients with epithelial solid tumors (EVOLVE).

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作者： Jean-Pascal,Machiels ^[1] ; Ramon,Salazar ^[2] ; Sylvie,Rottey ^[3] ; Ignacio,Duran ^[4] ; Luc,Dirix ^[5] ; Karen,Geboes ^[6] ; Christine,Wilkinson-Blanc ^[7] ; Gillian,Pover ^[7] ; Simon,Alvis ^[7] ; Brian,Champion ^[8] ; Kerry,Fisher ^[7] ; Hilary,McElwaine-Johnn ^[9] ; John,Beadle ^[7] ; Emiliano,Calvo ^[7]

作者单位： Department of Medical Oncology, Institut Roi Albert II, Cliniques universitaires Saint-Luc and Institut de Recherche Clinique et Expérimentale, Université catholique de Louvain, Brussels, Belgium. ^[1] Medical Oncology Department, Catalan Institute of Oncology, IDIBELL, University of Barcelona, Barcelona, Spain. ^[2] Drug Research Unit Ghent, Ghent University Hospital, Ghent, Belgium. ^[3] Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain. ^[4] Saint-Augustinus Hospital, Antwerp, Belgium. ^[5] Department of Gastroenterology and Digestive Oncology, Ghent University Hospital, Ghent, Belgium. ^[6] PsiOxus Therapeutics Limited, 4-10 The Quadrant, Barton Lane, Abingdon, UK. ^[7] PsiOxus Therapeutics Limited, 4-10 The Quadrant, Barton Lane, Abingdon, UK. Brian.Champion@psioxus.com. ^[8] Department of Oncology, University of Oxford, Oxford, UK. ^[9] START Madrid, Centro Integral Oncológico Clara Campal, Hospital Madrid Norte Sanchinarro, Madrid, Spain. ^[10]

关键词 Clinical trials Enadenotucirev Epithelial solid tumor Intravenous Oncolytic adenovirus Pharmacokinetics and pharmacodynamics

主题词腺病毒科(Adenoviridae);成年人(Adult);老年人(Aged);细胞因子类(Cytokines);女(雌)性(Female);人类(Humans);男(雄)性(Male);最大耐受剂量(Maximum Tolerated Dose);中年人(Middle Aged);肿瘤, 腺和上皮(Neoplasms, Glandular and Epithelial);溶瘤病毒疗法(Oncolytic Virotherapy);溶瘤病毒(Oncolytic Viruses)

DOI 10.1186/s40425-019-0510-7

PMID 30691536

发布时间 2024-02-10

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Journal for immunotherapy of cancer

2019年7卷1期

20页

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A phase 1 dose escalation study of the oncolytic adenovirus enadenotucirev, administered intravenously to patients with epithelial solid tumors (EVOLVE).

Journal for immunotherapy of cancer

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Journal for immunotherapy of cancer

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A phase 1 dose escalation study of the oncolytic adenovirus enadenotucirev, administered intravenously to patients with epithelial solid tumors (EVOLVE).

Journal for immunotherapy of cancer

相似文献

Journal for immunotherapy of cancer

相关期刊

检索历史清除