TBX3 promotes progression of pre-invasive breast cancer cells by inducing EMT and directly up-regulating SLUG.

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第一作者： Milica,Krstic

第一单位： Department of Oncology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.;The Pamela Greenaway-Kohlmeier Translational Breast Cancer Research Unit, London Regional Cancer Program, London Health Sciences Centre, London, ON, Canada.;Department of Pathology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.

作者： Milica,Krstic ^[1] ; Bart,Kolendowski ^[2] ; Matthew J,Cecchini ^[3] ; Carl O,Postenka ^[4] ; Haider M,Hassan ^[5] ; Joseph,Andrews ^[4] ; Connor D,MacMillan ^[6] ; Karla C,Williams ^[7] ; Hon S,Leong ^[8] ; Muriel,Brackstone ^[9] ; Joseph,Torchia ^[10] ; Ann F,Chambers ^[1] ; Alan B,Tuck ^[1]

作者单位： Department of Oncology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.;The Pamela Greenaway-Kohlmeier Translational Breast Cancer Research Unit, London Regional Cancer Program, London Health Sciences Centre, London, ON, Canada.;Department of Pathology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. ^[1] Department of Oncology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.;The Pamela Greenaway-Kohlmeier Translational Breast Cancer Research Unit, London Regional Cancer Program, London Health Sciences Centre, London, ON, Canada.;Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.;Mary & John Knight Translational Ovarian Cancer Research Unit, London Regional Cancer Program, London Health Sciences Centre, London, ON, Canada. ^[2] Department of Pathology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. ^[3] Department of Oncology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.;The Pamela Greenaway-Kohlmeier Translational Breast Cancer Research Unit, London Regional Cancer Program, London Health Sciences Centre, London, ON, Canada. ^[4] Department of Oncology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.;Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. ^[5] Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada. ^[6] Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada. ^[7] Departments of Urology, Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. ^[8] Department of Oncology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. ^[9] Department of Oncology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.;The Pamela Greenaway-Kohlmeier Translational Breast Cancer Research Unit, London Regional Cancer Program, London Health Sciences Centre, London, ON, Canada.;Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. ^[10]

关键词 SLUG TBX3 breast cancer ductal carcinoma in situ (DCIS)epithelial-to-mesenchymal transition (EMT)