Synthesis of novel pyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT<sub>1A</sub> receptor ligands.

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作者： Grzegorz,Ślifirski ^[1] ; Marek,Król ^[2] ; Jerzy,Kleps ^[1] ; Szymon,Ulenberg ^[3] ; Mariusz,Belka ^[3] ; Tomasz,Bączek ^[3] ; Agata,Siwek ^[4] ; Katarzyna,Stachowicz ^[4] ; Bernadeta,Szewczyk ^[4] ; Gabriel,Nowak ^[5] ; Andrzej,Bojarski ^[4] ; Anna E,Kozioł ^[6] ; Jadwiga,Turło ^[1] ; Franciszek,Herold ^[1]

作者单位： Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1, Banacha Street, 02-097 Warsaw, Poland. ^[1] Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1, Banacha Street, 02-097 Warsaw, Poland. Electronic address: marek.krol@wum.edu.pl. ^[2] Department of Pharmaceutical Chemistry, Medical University of Gdańsk, 107, J. Hallera Street, 80-416 Gdańsk, Poland. ^[3] Institute of Pharmacology, Polish Academy of Sciences, 12, Smętna Street, 31-343 Kraków, Poland. ^[4] Institute of Pharmacology, Polish Academy of Sciences, 12, Smętna Street, 31-343 Kraków, Poland; Jagiellonian University Medical College, 9, Medyczna Street, 30-688 Kraków, Poland. ^[5] Faculty of Chemistry, Maria Curie-Skłodowska University, 3, M. Curie-Skłodowskiej Sq., 20-031 Lublin, Poland. ^[6]

关键词 Antidepressants Dual 5-HT(1A)/SERT activity Pyrido[1,2-c]pyrimidines