S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability of cancer stem cells.

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第一作者： Elena,Strekalova

第一单位： Department of Medicine, University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

作者： Elena,Strekalova ^[1] ; Dmitry,Malin ^[1] ; Erin M M,Weisenhorn ^[2] ; Jason D,Russell ^[3] ; Dominik,Hoelper ^[2] ; Aayushi,Jain ^[2] ; Joshua J,Coon ^[4] ; Peter W,Lewis ^[2] ; Vincent L,Cryns ^[5]

作者单位： Department of Medicine, University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. ^[1] Department of Biomolecular Chemistry, University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. ^[2] Morgridge Institute for Research, Madison, WI, USA.;Genome Center of Wisconsin, University of Wisconsin-Madison, Madison, WI, USA. ^[3] Department of Biomolecular Chemistry, University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.;Morgridge Institute for Research, Madison, WI, USA.;Genome Center of Wisconsin, University of Wisconsin-Madison, Madison, WI, USA.;Department of Chemistry, University of Wisconsin-Madison, Madison, WI, USA. ^[4] Department of Medicine, University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. vlcryns@medicine.wisc.edu.;Department of Medicine, University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, MFCB 4144, 1685 Highland Avenue, Madison, WI, 53705, USA. vlcryns@medicine.wisc.edu. ^[5]

关键词 Breast cancer Cancer stem cell Methionine Nutrition S-adenosylmethionine Therapeutics