首页> Human pathology> Silencing the GUCA2A-GUCY2C tumor suppressor axis in CIN, serrated, and MSI colorectal neoplasia.

Silencing the GUCA2A-GUCY2C tumor suppressor axis in CIN, serrated, and MSI colorectal neoplasia.

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第一作者： Babar,Bashir

第一单位： Department of Pharmacology & Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, United States; Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA 19107, United States. Electronic address: babar.bashir@jefferson.edu.

作者： Babar,Bashir ^[1] ; Dante J,Merlino ^[2] ; Jeffrey A,Rappaport ^[3] ; Esteban,Gnass ^[4] ; Juan P,Palazzo ^[5] ; Ying,Feng ^[6] ; Eric R,Fearon ^[7] ; Adam E,Snook ^[8] ; Scott A,Waldman ^[9]

作者单位： Department of Pharmacology & Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, United States; Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA 19107, United States. Electronic address: babar.bashir@jefferson.edu. ^[1] Department of Pharmacology & Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, United States. Electronic address: dante.merlino@jefferson.edu. ^[2] Department of Pharmacology & Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, United States. Electronic address: jeffrey.rappaport@jefferson.edu. ^[3] Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, United States. Electronic address: estebandgnass@gmail.com. ^[4] Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, United States. Electronic address: juan.palazzo@jefferson.edu. ^[5] Departments of Internal Medicine and Pathology, University of Michigan, Ann Arbor, MI 48109, United States. Electronic address: yingfeng@med.umich.edu. ^[6] Departments of Internal Medicine and Pathology, University of Michigan, Ann Arbor, MI 48109, United States; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, United States. Electronic address: fearon@med.umich.edu. ^[7] Department of Pharmacology & Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, United States. Electronic address: adam.snook@jefferson.edu. ^[8] Department of Pharmacology & Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, United States. Electronic address: scott.waldman@jefferson.edu. ^[9]

关键词 CDX2 Colorectal cancer Guanylate cyclase C Guanylin Serrated adenoma Tubular adenoma

医学主题词腺瘤(Adenoma);成年人(Adult);老年人(Aged);动物(Animals);结直肠肿瘤(Colorectal Neoplasms);女(雌)性(Female);人类(Humans);男(雄)性(Male);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);中年人(Middle Aged);信号传导(Signal Transduction)

DOI 10.1016/j.humpath.2018.11.032

PMID 30716341

发布时间 2020-05-01

基金项目

F30 CA232469/CA/NCI NIH HHS/United States R01 CA206026/CA/NCI NIH HHS/United States T32 GM008562/GM/NIGMS NIH HHS/United States R01 CA204481/CA/NCI NIH HHS/United States F30 DK103492/DK/NIDDK NIH HHS/United States P30 CA056036/CA/NCI NIH HHS/United States

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