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Defining the impact of mutation accumulation on replicative lifespan in yeast using cancer-associated mutator phenotypes.

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第一作者： Mitchell B,Lee

第一单位： Department of Pathology, University of Washington, Seattle, WA 98195-7705.

作者： Mitchell B,Lee ^[1] ; Ian T,Dowsett ^[2] ; Daniel T,Carr ^[1] ; Brian M,Wasko ^[3] ; Sarah G,Stanton ^[1] ; Michael S,Chung ^[1] ; Niloufar,Ghodsian ^[1] ; Anna,Bode ^[1] ; Michael G,Kiflezghi ^[2] ; Priya A,Uppal ^[1] ; Katherine A,Grayden ^[1] ; Yordanos C,Elala ^[1] ; Thao T,Tang ^[1] ; Ngoc H B,Tran ^[1] ; Thu H B,Tran ^[1] ; Anh B,Diep ^[1] ; Michael,Hope ^[1] ; Daniel E L,Promislow ^[4] ; Scott R,Kennedy ^[1] ; Matt,Kaeberlein ^[1] ; Alan J,Herr ^[5]

作者单位： Department of Pathology, University of Washington, Seattle, WA 98195-7705. ^[1] Department of Pathology, University of Washington, Seattle, WA 98195-7705.;Molecular Medicine and Mechanisms of Disease Program, University of Washington, Seattle, WA 98195-7705. ^[2] Department of Pathology, University of Washington, Seattle, WA 98195-7705.;Department of Biology and Biotechnology, University of Houston-Clear Lake, Houston, TX 77058. ^[3] Department of Pathology, University of Washington, Seattle, WA 98195-7705.;Department of Biology, University of Washington, Seattle, WA, 98195-1800. ^[4] Department of Pathology, University of Washington, Seattle, WA 98195-7705; alanherr@uw.edu. ^[5]

关键词 aging mismatch repair mutation accumulation polymerase proofreading replicative lifespan