A strategy for generating cancer-specific monoclonal antibodies to aberrant O-glycoproteins: identification of a novel dysadherin-Tn antibody.

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作者： Catharina,Steentoft ^[1] ; Max,Fuhrmann ^[1] ; Federico,Battisti ^[2] ; Julie,Van Coillie ^[1] ; Thomas D,Madsen ^[1] ; Diana,Campos ^[3] ; Adnan,Halim ^[4] ; Sergey Y,Vakhrushev ^[1] ; Hiren J,Joshi ^[1] ; Hans,Schreiber ^[1] ; Ulla,Mandel ^[5] ; Yoshiki,Narimatsu ^[1]

作者单位： Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine and Odontology, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen N, Denmark. ^[1] Department of Experimental Medicine, "Sapienza" University of Rome, Viale Regina Elena 324 Rome, Italy. ^[2] Instituto de Investigação e Inovação e Saúde, Universidade do Porto, Rua Júlio Amaral de Carvalho 45, Porto, Portugal. ^[3] IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Rua Júlio Amaral de Carvalho 45, Porto, Portugal. ^[4] Department of Pathology, Committee on Immunology, Committee on Cancer Biology, The University of Chicago, 5841 S. Maryland Avenue, Chicago, IL, USA. ^[5]

关键词 CRISPR-CAS9 FXYD5 GalNAc-T7 SimpleCell dysadherin