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Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity.

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作者单位: Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium. [1] Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium. [2] Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium. [3] Myeloid Cell Immunology Laboratory, VIB Center for Inflammation Research, Brussels, Belgium. [4] Tsukishima Foods Industry, Tokyo, Japan. [5] Cluster of Agricultural Sciences, Faculty of Food and Agricultural Sciences, Fukushima University, Fukushima, Japan. [6] Laboratory of Lipid Metabolism and Cancer, Department of Oncology, Leuven Cancer Institute (LKI), Leuven, Belgium. [7] The Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK. [8] Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. [9] Stem Cell Institute, Department of Development and Regeneration, KU Leuven, Leuven, Belgium. [10] VIB Bio Imaging Core and VIB-KU Leuven Center for Brain & Disease Research, KU Leuven, Leuven, Belgium. [11] Molecular Neurobiology, Department of Neuroscience, KU Leuven, Leuven, Belgium. [12] Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. [13] Children's Medical Center Research Institute, UT Southwestern, Dallas, TX, USA. [14] The Francis Crick Institute, London, UK. [15] Bayer AG, Research & Development, Pharmaceuticals, Berlin, Germany. [16] Perlmutter Cancer Center, NYU Langone Medical Center, Smilow Research Center, New York, NY, USA. [17] Laboratory of Pediatric Hepatology and Cell Therapy, Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain and Cliniques Universitaires St Luc, Brussels, Belgium. [18] Department of Food Science and Technology, Tokyo University of Marine Science and Technology, Tokyo, Japan. [19] Laboratory of Protein Phosphorylation and Proteomics, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium. [20] Howard Hughes Medical Institute, UT Southwestern Medical Center, Dallas, TX, USA. [21] Department of Hepatology, KU Leuven, Leuven, Belgium. [22] Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium. [23] Department of Digestive Oncology, KU Leuven, Leuven, Belgium. [24] Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. [25] German Cancer Consortium (DKTK), Partner site Munich, Munich, Germany. [26] German Cancer Research Center (DKFZ), Heidelberg, Germany. [27] Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium. sarah-maria.fendt@kuleuven.vib.be. [28] Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium. sarah-maria.fendt@kuleuven.vib.be. [29]
DOI 10.1038/s41586-019-0904-1
PMID 30728499
发布时间 2022-02-23
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