首页> Oncotarget> Optimal targeting of BCL-family proteins in head and neck squamous cell carcinoma requires inhibition of both BCL-xL and MCL-1.

Optimal targeting of BCL-family proteins in head and neck squamous cell carcinoma requires inhibition of both BCL-xL and MCL-1.

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第一作者： Thomas J,Ow

第一单位： Department of Otorhinolaryngology-Head and Neck Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.;Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.;Albert Einstein Cancer Center, Bronx, NY, USA.

作者： Thomas J,Ow ^[1] ; Cory D,Fulcher ^[2] ; Carlos,Thomas ^[3] ; Pilib Ó,Broin ^[4] ; Andrea,López ^[5] ; Denis E,Reyna ^[5] ; Richard V,Smith ^[6] ; Catherine,Sarta ^[2] ; Michael B,Prystowsky ^[7] ; Nicolas F,Schlecht ^[8] ; Bradley A,Schiff ^[2] ; Gregory,Rosenblatt ^[3] ; Thomas J,Belbin ^[9] ; Thomas M,Harris ^[3] ; Geoffrey C,Childs ^[3] ; Nicole,Kawachi ^[3] ; Chandan,Guha ^[10] ; Evripidis,Gavathiotis ^[11]

作者单位： Department of Otorhinolaryngology-Head and Neck Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.;Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.;Albert Einstein Cancer Center, Bronx, NY, USA. ^[1] Department of Otorhinolaryngology-Head and Neck Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA. ^[2] Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA. ^[3] School of Mathematics, Statistics, and Applied Mathematics, National University of Ireland Galway, Galway, Ireland. ^[4] Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA. ^[5] Department of Otorhinolaryngology-Head and Neck Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.;Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.;Department of Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.;Albert Einstein Cancer Center, Bronx, NY, USA. ^[6] Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.;Albert Einstein Cancer Center, Bronx, NY, USA. ^[7] Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.;Department of Epidemiology & Population Health, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.;Department of Medicine (Oncology), Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.;Department of Cancer Prevention & Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. ^[8] Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.;Discipline of Oncology, Memorial University of Newfoundland, St. John's, NL, Canada. ^[9] Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.;Department of Radiation Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.;Albert Einstein Cancer Center, Bronx, NY, USA. ^[10] Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.;Department of Medicine (Cardiology), Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.;Albert Einstein Cancer Center, Bronx, NY, USA. ^[11]

关键词 A-1210477 BCL-xL MCL-1 head and neck squamous carcinoma navitoclax

DOI 10.18632/oncotarget.26563

PMID 30728900

发布时间 2026-02-26

基金项目

P30 CA016056/CA/NCI NIH HHS/United States R01 CA178394/CA/NCI NIH HHS/United States K23 DE027425/DE/NIDCR NIH HHS/United States T32 GM007491/GM/NIGMS NIH HHS/United States K12 CA132783/CA/NCI NIH HHS/United States UL1 TR002556/TR/NCATS NIH HHS/United States P30 CA013330/CA/NCI NIH HHS/United States

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