Regional protein expression in human Alzheimer's brain correlates with disease severity.-论文-万方医学网

第一作者： Jingshu,Xu

第一单位： 1Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Sciences Centre, Core Technology Facility (3rd Floor), 46 Grafton Street, Manchester, M13 9NT UK.;2School of Biological Sciences, and Maurice Wilkins Centre for Molecular Biodiscovery, Faculty of Science, University of Auckland, Private Bag 92019, Auckland, 1142 New Zealand.

作者： Jingshu,Xu ^[1] ; Stefano,Patassini ^[1] ; Nitin,Rustogi ^[2] ; Isabel,Riba-Garcia ^[2] ; Benjamin D,Hale ^[2] ; Alexander M,Phillips ^[3] ; Henry,Waldvogel ^[4] ; Robert,Haines ^[5] ; Phil,Bradbury ^[5] ; Adam,Stevens ^[6] ; Richard L M,Faull ^[4] ; Andrew W,Dowsey ^[7] ; Garth J S,Cooper ^[8] ; Richard D,Unwin ^[2]

作者单位： 1Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Sciences Centre, Core Technology Facility (3rd Floor), 46 Grafton Street, Manchester, M13 9NT UK.;2School of Biological Sciences, and Maurice Wilkins Centre for Molecular Biodiscovery, Faculty of Science, University of Auckland, Private Bag 92019, Auckland, 1142 New Zealand. ^[1] 1Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Sciences Centre, Core Technology Facility (3rd Floor), 46 Grafton Street, Manchester, M13 9NT UK. ^[2] 3Department of Electrical Engineering and Electronics, University of Liverpool, Liverpool, L69 3GJ UK. ^[3] 4Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Auckland, 1142 New Zealand. ^[4] 5Research IT, The University of Manchester, Manchester, M13 9PL UK. ^[5] 6Division of Developmental Biology & Medicine, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, M13 9PL UK. ^[6] 1Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Sciences Centre, Core Technology Facility (3rd Floor), 46 Grafton Street, Manchester, M13 9NT UK.;7Department of Population Health Sciences and Bristol Veterinary School, Faculty of Health Sciences, University of Bristol, Bristol, BS8 2BN UK. ^[7] 1Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Sciences Centre, Core Technology Facility (3rd Floor), 46 Grafton Street, Manchester, M13 9NT UK.;2School of Biological Sciences, and Maurice Wilkins Centre for Molecular Biodiscovery, Faculty of Science, University of Auckland, Private Bag 92019, Auckland, 1142 New Zealand.;4Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Auckland, 1142 New Zealand. ^[8]

医学主题词老年人(Aged);老年人, 80以上(Aged, 80 and over);阿尔茨海默病(Alzheimer Disease);尸体解剖(Autopsy);病例对照研究(Case-Control Studies);小脑(Cerebellum);疾病恶化(Disease Progression);内嗅皮层(Entorhinal Cortex);女(雌)性(Female);基因表达谱(Gene Expression Profiling);基因表达调控(Gene Expression Regulation);基因调控网络(Gene Regulatory Networks);扣带回(Gyrus Cinguli);海马(Hippocampus);人类(Humans);男(雄)性(Male);中年人(Middle Aged);运动皮质(Motor Cortex);神经组织蛋白质类(Nerve Tissue Proteins);器官特异性(Organ Specificity);信号传导(Signal Transduction);躯体感觉皮质(Somatosensory Cortex)

DOI 10.1038/s42003-018-0254-9

PMID 30729181

发布时间 2025-05-30

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Regional protein expression in human Alzheimer's brain correlates with disease severity.

Communications biology

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Regional protein expression in human Alzheimer's brain correlates with disease severity.

Communications biology

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Communications biology

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