Genome-wide methylotyping resolves breast cancer epigenetic heterogeneity and suggests novel therapeutic perspectives.

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第一作者： Alexander S,Tanas

第一单位： Epigenetics Laboratory, Research Centre for Medical Genetics, Moscow, Russia.

作者： Alexander S,Tanas ^[1] ; Vladimir O,Sigin ^[2] ; Alexey I,Kalinkin ^[1] ; Nikolai V,Litviakov ^[1] ; Elena M,Slonimskaya ^[3] ; Marina K,Ibragimova ^[4] ; Ekaterina O,Ignatova ^[5] ; Olga A,Simonova ^[4] ; Ekaterina B,Kuznetsova ^[6] ; Tatiana V,Kekeeva ^[1] ; Sergey S,Larin ^[1] ; Elena V,Poddubskaya ^[3] ; Ivan D,Trotsenko ^[1] ; Viktoria V,Rudenko ^[7] ; Kristina O,Karandasheva ^[8] ; Kseniya D,Petrova ^[9] ; Matvey M,Tsyganov ^[10] ; Irina V,Deryusheva ^[11] ; Polina V,Kazantseva ^[1] ; Artem V,Doroshenko ^[1] ; Natalia A,Tarabanovskaya ^[1] ; Galina G,Chesnokova ^[12] ; Marina I,Sekacheva ^[4] ; Marina V,Nemtsova ^[4] ; Vera L,Izhevskaya ^[5] ; Sergey I,Kutsev ^[5] ; Dmitry V,Zaletaev ^[5] ; Vladimir V,Strelnikov ^[1]

作者单位： Epigenetics Laboratory, Research Centre for Medical Genetics, Moscow, Russia. ^[1] Molecular & Cell Genetics Department, Pirogov Russian National Research Medical University, Moscow, Russia. ^[2] Medical Genetics Laboratory, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia. ^[3] Laboratory of Oncovirology, Cancer Research Institute, Tomsk National Research Medical Center, Tomsk, Russia. ^[4] Department of General Oncology, Cancer Research Institute, Tomsk National Research Medical Center, Tomsk, Russia. ^[5] Clinical Pharmacology & Chemotherapy, Federal State Budgetary institution «N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation, Moscow, Russia. ^[6] Gene Therapy Laboratory, Institute of Gene Biology, Moscow, Russia. ^[7] Molecular Immunology Laboratory, Federal Scientific Clinical Centre of Pediatric Hematology Oncology Immunology Named after Dmitry Rogachev, Moscow, Russia. ^[8] Clinic of Personalized Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia. ^[9] VitaMed LLC, Moscow, Russia. ^[10] Institute of Medicine, RUDN University, Moscow, Russia. ^[11] Department of Biological and Medical Physics, Moscow Institute of Physics & Technology (State University), Dolgoprudny, Moscow Region, Russia. ^[12]

关键词 5-fluorouracil DNA methylation DNA methylotype XmaI-RRBS adenylate cyclase pathway breast cancer cancer cell lines leukotriene receptors reduced representation bisulfite sequencing resveratrol

主题词乳腺肿瘤(Breast Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);聚类分析(Cluster Analysis);DNA甲基化(DNA Methylation);后成说, 遗传(Epigenesis, Genetic);女(雌)性(Female);人类(Humans)

DOI 10.2217/epi-2018-0213

PMID 30729807

发布时间 2020-06-30

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准确一般字义偏差语意偏离译文作用小提交