Immune Response and Intraocular Inflammation in Patients With Leber Hereditary Optic Neuropathy Treated With Intravitreal Injection of Recombinant Adeno-Associated Virus 2 Carrying the ND4 Gene: A Secondary Analysis of a Phase 1/2 Clinical Trial.-论文-万方医学网

作者： Céline,Bouquet ^[1] ; Catherine,Vignal Clermont ^[2] ; Anne,Galy ^[3] ; Serge,Fitoussi ^[1] ; Laure,Blouin ^[1] ; Marion R,Munk ^[1] ; Sonia,Valero ^[4] ; Sandrine,Meunier ^[5] ; Barrett,Katz ^[1] ; José Alain,Sahel ^[1] ; Nitza,Thomasson ^[1]

作者单位： GenSight Biologics, Paris, France. ^[1] Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris, France. ^[2] Rothschild Ophthalmology Foundation Hospital, Paris, France. ^[3] Department of Ophthalmology, Bern Photographic Reading Center, Bern, Switzerland. ^[4] Inselspital, University Hospital Bern Oberärztin, Bern, Switzerland. ^[5] Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Institut de la Vision, Paris, France. ^[6] Department of Ophthalmology, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. ^[7]

主题词依赖病毒(Dependovirus);视网膜电描记术(Electroretinography);女(雌)性(Female);荧光素血管造影术(Fluorescein Angiography);随访研究(Follow-Up Studies);眼底(Fundus Oculi);遗传载体(Genetic Vectors);人类(Humans);玻璃体内注射(Intravitreal Injections);男(雄)性(Male);中年人(Middle Aged);NADH脱氢酶(NADH Dehydrogenase);视神经萎缩, 遗传性, Leber(Optic Atrophy, Hereditary, Leber);细小病毒亚科(Parvovirinae);重组融合蛋白质类(Recombinant Fusion Proteins);视网膜神经节细胞(Retinal Ganglion Cells);回顾性研究(Retrospective Studies);体层摄影术, 光学相干(Tomography, Optical Coherence);视敏度(Visual Acuity);视野(Visual Fields)

DOI 10.1001/jamaophthalmol.2018.6902

PMID 30730541

发布时间 2021-12-04

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Immune Response and Intraocular Inflammation in Patients With Leber Hereditary Optic Neuropathy Treated With Intravitreal Injection of Recombinant Adeno-Associated Virus 2 Carrying the ND4 Gene: A Secondary Analysis of a Phase 1/2 Clinical Trial.

JAMA ophthalmology

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JAMA ophthalmology

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Immune Response and Intraocular Inflammation in Patients With Leber Hereditary Optic Neuropathy Treated With Intravitreal Injection of Recombinant Adeno-Associated Virus 2 Carrying the ND4 Gene: A Secondary Analysis of a Phase 1/2 Clinical Trial.

JAMA ophthalmology

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JAMA ophthalmology

相关期刊

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