EDA fibronectin-TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis.

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作者： Alessandro,Malara ^[1] ; Cristian,Gruppi ^[2] ; Vittorio,Abbonante ^[1] ; Daniele,Cattaneo ^[3] ; Luigi,De Marco ^[4] ; Margherita,Massa ^[5] ; Alessandra,Iurlo ^[3] ; Umberto,Gianelli ^[6] ; Carlo L,Balduini ^[7] ; Maria E,Tira ^[8] ; Andrès F,Muro ^[9] ; Anil K,Chauhan ^[10] ; Vittorio,Rosti ^[11] ; Giovanni,Barosi ^[11] ; Alessandra,Balduini ^[12]

作者单位： Department of Molecular Medicine, University of Pavia, Pavia, Italy.;Laboratory of Biochemistry, Biotechnology and Advanced Diagnostics, Istituto di Ricovero e Cura a Carattere Scientific San Matteo Foundation, Pavia, Italy. ^[1] Department of Molecular Medicine, University of Pavia, Pavia, Italy. ^[2] Hematology Division, Istituto di Ricovero e Cura a Carattere Scientific Ca' Granda-Maggiore Policlinico Hospital Foundation, Milan, Italy. ^[3] Department of Translational Research, National Cancer Center (Istituto di Ricovero e Cura a Carattere Scientific Centro di Riferimento Oncologico), Aviano, Italy.;Department of Molecular and Experimental Research, The Scripps Research Institute, La Jolla, CA. ^[4] Laboratory of Biochemistry, Biotechnology and Advanced Diagnostics, Istituto di Ricovero e Cura a Carattere Scientific San Matteo Foundation, Pavia, Italy. ^[5] Division of Pathology, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy. ^[6] Department of Internal Medicine, Istituto di Ricovero e Cura a Carattere Scientific San Matteo Foundation, Pavia, Italy. ^[7] Department of Biology and Biotechnology "Lazzaro Spallanzani," University of Pavia, Pavia, Italy. ^[8] The International Center for Genetic Engineering and Biotechnology, Trieste, Italy. ^[9] Department of Internal Medicine, University of Iowa, Iowa City, IA. ^[10] Center for the Study of Myelofibrosis, Laboratory of Biochemistry, Biotechnology and Advanced Diagnostics, Istituto di Ricovero e Cura a Carattere Scientific Policlinico S. Matteo Foundation, Pavia, Italy. ^[11] Department of Molecular Medicine, University of Pavia, Pavia, Italy alessandra.balduini@tufts.edu.;Laboratory of Biochemistry, Biotechnology and Advanced Diagnostics, Istituto di Ricovero e Cura a Carattere Scientific San Matteo Foundation, Pavia, Italy.;Department of Biomedical Engineering, Tufts University, Medford, MA. ^[12]